Sirtuin-1 (SIRT-1) is a protein that may orchestrate the cardioprotective effect of exercise by controlling cellular processes. This pilot study assessed the feasibility of performing a quasi-experimental study in this area. Post-acute myocardial infarction patients were recruited across four hospital sites in the United Kingdom. Participants were offered one weekly exercise session at phase-III and phase-IV cardiac rehabilitation (CR). Measurements were obtained pre-phase-III CR (week-1), post-phase-III CR (week-8), and post-phase-IV CR (week-22). Twenty-eight patients were recruited (79% male, 100% white, 60.2 ± 10.5 years old). Recruitment rate was not fulfilled (< 70% eligible patients recruited; 0.9 participants recruited per week over 30 weeks). Success criteria for drop-out rate, adherence rate, and collection of SIRT-1 measures were satisfied. A large increase in SIRT-1 (0.14 ± 0.03, d ≥ 0.8) was seen after phase-III and phase-IV CR. Collectively, a quasi-experimental study is feasible with a revised recruitment strategy.
|Journal||Journal of Aging and Physical Activity|
|Publication status||Accepted/In press - 14 May 2021|
- cardiac rehabilitation
- Endothelial function
- Molecular mechanisms