Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids

Gema Pereira-Caro; Salud Cáceres-Jimenez; Letizia Bresciani; Pedro Mena; Tahani M. Almutairi; Sara Dobani; L. Kirsty Pourshahidi; Chris I.R Gill; José Manuel Moreno Rojas; Michael N. Clifford; Alan Crozier

doi:10.1080/09637486.2023.2226369

Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids

Gema Pereira-Caro, Salud Cáceres-Jimenez, Letizia Bresciani, Pedro Mena, Tahani M. Almutairi, Sara Dobani, L. Kirsty Pourshahidi, Chris I.R Gill, José Manuel Moreno Rojas, Michael N. Clifford, Alan Crozier

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

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Abstract

Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12 h fasting period after adherence to a low (poly)phenol diet for 36 h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-µmol amounts, but hippuric acid dominated accounting on average for 60% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.

Original language	English
Pages (from-to)	532-543
Number of pages	12
Journal	International Journal of Food Sciences and Nutrition
Volume	74
Issue number	4
Early online date	27 Jun 2023
DOIs	https://doi.org/10.1080/09637486.2023.2226369
Publication status	Published online - 27 Jun 2023

Bibliographical note

Funding Information:
A.C., T.M.A. and G.P.-C. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. G.P.-C. was also supported by the grant RTI2018-096703-J-I00 from the Spanish State Research Agency (AEI) and by the ‘Programa Emergia 2020’ from the Secretaría General de Universidades, Investigación e Innovación, Junta de Andalucía. S.C.-J. is supported by a predoctoral fellowship funded by the Spanish Ministry of Universities (FPU20/03549).

Publisher Copyright:
© 2023 Taylor & Francis Group, LLC.

Funding

Funding Information: A.C., T.M.A. and G.P.-C. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. G.P.-C. was also supported by the grant RTI2018-096703-J-I00 from the Spanish State Research Agency (AEI) and by the ‘Programa Emergia 2020’ from the Secretaría General de Universidades, Investigación e Innovación, Junta de Andalucía. S.C.-J. is supported by a predoctoral fellowship funded by the Spanish Ministry of Universities (FPU20/03549). Publisher Copyright: © 2023 Taylor & Francis Group, LLC.

Keywords

Low (poly)phenol diet
excretion of phenolics
UHPLC-HR-MS
presence and absence of a Colon
catecholamines
tyrosine
phenylalanine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/09637486.2023.2226369

Excretion by subjects on a low poly phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines andFinal published version, 2.36 MBLicence: CC BY

Cite this

Pereira-Caro, G., Cáceres-Jimenez, S., Bresciani, L., Mena, P., Almutairi, T. M., Dobani, S., Pourshahidi, L. K., Gill, C. I. R., Moreno Rojas, J. M., Clifford, M. N., & Crozier, A. (2023). Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids. International Journal of Food Sciences and Nutrition, 74(4), 532-543. Advance online publication. https://doi.org/10.1080/09637486.2023.2226369

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abstract = "Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12 h fasting period after adherence to a low (poly)phenol diet for 36 h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-µmol amounts, but hippuric acid dominated accounting on average for 60\% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.",

keywords = "Low (poly)phenol diet, excretion of phenolics, UHPLC-HR-MS, presence and absence of a Colon, catecholamines, tyrosine, phenylalanine",

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note = "Funding Information: A.C., T.M.A. and G.P.-C. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. G.P.-C. was also supported by the grant RTI2018-096703-J-I00 from the Spanish State Research Agency (AEI) and by the {\textquoteleft}Programa Emergia 2020{\textquoteright} from the Secretar{\'i}a General de Universidades, Investigaci{\'o}n e Innovaci{\'o}n, Junta de Andaluc{\'i}a. S.C.-J. is supported by a predoctoral fellowship funded by the Spanish Ministry of Universities (FPU20/03549). Publisher Copyright: {\textcopyright} 2023 Taylor \& Francis Group, LLC.",

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Pereira-Caro, G, Cáceres-Jimenez, S, Bresciani, L, Mena, P, Almutairi, TM, Dobani, S, Pourshahidi, LK , Gill, CIR, Moreno Rojas, JM, Clifford, MN & Crozier, A 2023, 'Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids', International Journal of Food Sciences and Nutrition, vol. 74, no. 4, pp. 532-543. https://doi.org/10.1080/09637486.2023.2226369

Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids. / Pereira-Caro, Gema; Cáceres-Jimenez, Salud; Bresciani, Letizia et al.
In: International Journal of Food Sciences and Nutrition, Vol. 74, No. 4, 27.06.2023, p. 532-543.

Research output: Contribution to journal › Article › peer-review

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AU - Cáceres-Jimenez, Salud

AU - Bresciani, Letizia

AU - Mena, Pedro

AU - Almutairi, Tahani M.

AU - Dobani, Sara

AU - Pourshahidi, L. Kirsty

AU - Gill, Chris I.R

AU - Moreno Rojas, José Manuel

AU - Clifford, Michael N.

AU - Crozier, Alan

N1 - Funding Information: A.C., T.M.A. and G.P.-C. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. G.P.-C. was also supported by the grant RTI2018-096703-J-I00 from the Spanish State Research Agency (AEI) and by the ‘Programa Emergia 2020’ from the Secretaría General de Universidades, Investigación e Innovación, Junta de Andalucía. S.C.-J. is supported by a predoctoral fellowship funded by the Spanish Ministry of Universities (FPU20/03549). Publisher Copyright: © 2023 Taylor & Francis Group, LLC.

PY - 2023/6/27

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N2 - Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12 h fasting period after adherence to a low (poly)phenol diet for 36 h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-µmol amounts, but hippuric acid dominated accounting on average for 60% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.

AB - Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12 h fasting period after adherence to a low (poly)phenol diet for 36 h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-µmol amounts, but hippuric acid dominated accounting on average for 60% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.

KW - Low (poly)phenol diet

KW - excretion of phenolics

KW - UHPLC-HR-MS

KW - presence and absence of a Colon

KW - catecholamines

KW - tyrosine

KW - phenylalanine

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Pereira-Caro G, Cáceres-Jimenez S, Bresciani L, Mena P, Almutairi TM, Dobani S et al. Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids. International Journal of Food Sciences and Nutrition. 2023 Jun 27;74(4):532-543. Epub 2023 Jun 27. doi: 10.1080/09637486.2023.2226369

Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

VALGUT: phenyl-ϒ-valerolactones are microbiota-derived compounds that can impact gut health

Cite this

Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Student theses

VALGUT: phenyl-ϒ-valerolactones are microbiota-derived compounds that can impact gut health

Cite this