Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals

Charles S. Bockman; Peter W. Abel; James W. Hicks; J. Michael Conlon

doi:10.1016/0014-2999(89)90117-9

Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals

Charles S. Bockman, Peter W. Abel, James W. Hicks, J. Michael Conlon

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Neuromedin U-8 induced a monophasic and concentration-dependent contraction of intact small intestine from the turtle, Pseudemys scripta, whereas the peptide had no effect upon the motility of rat and guinea pig gut. The maximum response produced by neuromedin U-8 was 56% of that produced by acetylcholine and 62% of that produced by potassium chloride. The potency and maximum response to neuromedin U-8 were unaffected by tetrodotoxin and atropine. The data suggest that neuromedin U may play a role in regulation of gut motility in lower vertebrates but not in mammals.

Original language	English
Pages (from-to)	255-257
Number of pages	3
Journal	European Journal of Pharmacology
Volume	171
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(89)90117-9
Publication status	Published (in print/issue) - 21 Nov 1989

Keywords

(Turtle)
Gut motility
Neuromedin U

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10.1016/0014-2999(89)90117-9

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title = "Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals",

abstract = "Neuromedin U-8 induced a monophasic and concentration-dependent contraction of intact small intestine from the turtle, Pseudemys scripta, whereas the peptide had no effect upon the motility of rat and guinea pig gut. The maximum response produced by neuromedin U-8 was 56% of that produced by acetylcholine and 62% of that produced by potassium chloride. The potency and maximum response to neuromedin U-8 were unaffected by tetrodotoxin and atropine. The data suggest that neuromedin U may play a role in regulation of gut motility in lower vertebrates but not in mammals.",

keywords = "(Turtle), Gut motility, Neuromedin U",

author = "Bockman, {Charles S.} and Abel, {Peter W.} and Hicks, {James W.} and Conlon, {J. Michael}",

year = "1989",

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T1 - Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals

AU - Bockman, Charles S.

AU - Abel, Peter W.

AU - Hicks, James W.

AU - Conlon, J. Michael

PY - 1989/11/21

Y1 - 1989/11/21

N2 - Neuromedin U-8 induced a monophasic and concentration-dependent contraction of intact small intestine from the turtle, Pseudemys scripta, whereas the peptide had no effect upon the motility of rat and guinea pig gut. The maximum response produced by neuromedin U-8 was 56% of that produced by acetylcholine and 62% of that produced by potassium chloride. The potency and maximum response to neuromedin U-8 were unaffected by tetrodotoxin and atropine. The data suggest that neuromedin U may play a role in regulation of gut motility in lower vertebrates but not in mammals.

AB - Neuromedin U-8 induced a monophasic and concentration-dependent contraction of intact small intestine from the turtle, Pseudemys scripta, whereas the peptide had no effect upon the motility of rat and guinea pig gut. The maximum response produced by neuromedin U-8 was 56% of that produced by acetylcholine and 62% of that produced by potassium chloride. The potency and maximum response to neuromedin U-8 were unaffected by tetrodotoxin and atropine. The data suggest that neuromedin U may play a role in regulation of gut motility in lower vertebrates but not in mammals.

KW - (Turtle)

KW - Gut motility

KW - Neuromedin U

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VL - 171

SP - 255

EP - 257

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals

Abstract

Keywords

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