Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis

Spencer Poore, Breanna Berry, Dabney Eidson, Katie T McKie, Ryan Harris

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    Abstract

    Background: Cystic fibrosis (CF) is a genetic disorder that affects not only pulmonary function, but also multiple organ systems. The flow-mediated dilation (FMD) test is a non-invasive assessment of endothelial function and nitric oxide bioavailability. Thus, the purpose of this study was to determine if 1) endothelial dysfunction is present in young patients with CF, and 2) endothelial function is associated with pulmonary function and exercise capacity.Methods: 15 patients with CF and 15 demographically matched controls participated in this study. Spirometry, brachial artery FMD, and a maximal exercise capacity test on a cycle ergometer were performed on all subjects to determine pulmonary function, endothelial function, and exercise capacity, respectively.Results: No differences (p>0.05) in age, height, or BMI were observed between patients withCF and controls. FEV1 (% predicted), FEV1/FVC, and FEF25-75 were lower in patients with CF.VO2 peak (absolute and relative) was similar between groups; however, VO2 (% predicted andml/kg fat free mass/min) and peak workload were significantly (p
    Original languageEnglish
    Pages (from-to)939-946
    JournalChest
    Volume143
    Issue number4
    Publication statusPublished - Apr 2013

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    Poore, S., Berry, B., Eidson, D., McKie, K. T., & Harris, R. (2013). Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis. Chest, 143(4), 939-946.