Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis

Spencer Poore, Breanna Berry, Dabney Eidson, Katie T McKie, Ryan Harris

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Background: Cystic fibrosis (CF) is a genetic disorder that affects not only pulmonary function, but also multiple organ systems. The flow-mediated dilation (FMD) test is a non-invasive assessment of endothelial function and nitric oxide bioavailability. Thus, the purpose of this study was to determine if 1) endothelial dysfunction is present in young patients with CF, and 2) endothelial function is associated with pulmonary function and exercise capacity.Methods: 15 patients with CF and 15 demographically matched controls participated in this study. Spirometry, brachial artery FMD, and a maximal exercise capacity test on a cycle ergometer were performed on all subjects to determine pulmonary function, endothelial function, and exercise capacity, respectively.Results: No differences (p>0.05) in age, height, or BMI were observed between patients withCF and controls. FEV1 (% predicted), FEV1/FVC, and FEF25-75 were lower in patients with CF.VO2 peak (absolute and relative) was similar between groups; however, VO2 (% predicted andml/kg fat free mass/min) and peak workload were significantly (p
    LanguageEnglish
    Pages939-946
    JournalChest
    Volume143
    Issue number4
    Publication statusPublished - Apr 2013

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    Cystic Fibrosis
    Blood Vessels
    Lung
    Dilatation
    Exercise
    Inborn Genetic Diseases
    Brachial Artery
    Spirometry
    Workload
    Exercise Test
    Biological Availability
    Nitric Oxide
    Fats

    Cite this

    Poore, S., Berry, B., Eidson, D., McKie, K. T., & Harris, R. (2013). Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis. Chest, 143(4), 939-946.
    Poore, Spencer ; Berry, Breanna ; Eidson, Dabney ; McKie, Katie T ; Harris, Ryan. / Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis. In: Chest. 2013 ; Vol. 143, No. 4. pp. 939-946.
    @article{34f8ca05a38c4754a5f177ba41271e48,
    title = "Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis",
    abstract = "Background: Cystic fibrosis (CF) is a genetic disorder that affects not only pulmonary function, but also multiple organ systems. The flow-mediated dilation (FMD) test is a non-invasive assessment of endothelial function and nitric oxide bioavailability. Thus, the purpose of this study was to determine if 1) endothelial dysfunction is present in young patients with CF, and 2) endothelial function is associated with pulmonary function and exercise capacity.Methods: 15 patients with CF and 15 demographically matched controls participated in this study. Spirometry, brachial artery FMD, and a maximal exercise capacity test on a cycle ergometer were performed on all subjects to determine pulmonary function, endothelial function, and exercise capacity, respectively.Results: No differences (p>0.05) in age, height, or BMI were observed between patients withCF and controls. FEV1 ({\%} predicted), FEV1/FVC, and FEF25-75 were lower in patients with CF.VO2 peak (absolute and relative) was similar between groups; however, VO2 ({\%} predicted andml/kg fat free mass/min) and peak workload were significantly (p",
    author = "Spencer Poore and Breanna Berry and Dabney Eidson and McKie, {Katie T} and Ryan Harris",
    note = "Reference text: 1. Green D. Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J Appl Physiol 2005;99:1233-1234; discussion 1237-1238 2. Uehata A, Lieberman EH, Gerhard MD, et al. Noninvasive assessment of endotheliumdependent flow-mediated dilation of the brachial artery. Vascular Medicine 1997;2:87-92 3. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-1115 4. Peinado VI, Barbera JA, Ramirez J, et al. Endothelial dysfunction in pulmonary arteries of patients with mild COPD. Am J Physiol 1998;274:L908-913 5. Johnstone MT, Creager MA, Scales KM. Impaired endothelium-dependent vasodilation in patients with insuline-dependent diabetes mellitus. Circulation 1993;88:2510-2516 6. Maiorana A, O'Droscoll F, Taylor R, Green D. Exercise and the Nitric Oxide Vasodilator System. Sports Med 2003;33:1013-1035 7. Edwards DG, Schofield RS, Lennon SL, et al. Effect of exercise training on endothelial function in men with coronary artery disease. Am J Cardiol 2004;93:617-620 8. Guerci B, Kearney-Schwartz A, Bohme P, Zannad F, Drouin P. Endothelial dysfunction and type 2 diabetes. Part 1: physiology and methods for exploring the endothelial function. Diabetes Metab 2001;27:425-434 9. Wolff B, Lodziewski S, Bollmann T, Opitz CF, Ewert R. Impaired peripheral endothelial function in severe idiopathic pulmonary hypertension correlates with the pulmonary vascular response to inhaled iloprost. Am Heart J 2007;153:1088 e1081-1087 10. Dinh Xuan AT, Higenbottam TW, Pepke-Zaba J, Clelland C, Wallwork J. Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries. Eur J Pharmacol 1989;163:401-403 11. Henno P, Maurey C, Danel C, et al. Pulmonary vascular dysfunction in end-stage cystic fibrosis: role of NF-kappaB and endothelin-1. Eur Respir J 2009;34:1329-1337 12. Romano M, Collura M, Lapichino L, et al. Endothelial perturbation in cystic fibrosis. Thromb Haemost 2001;86:1363-1367 13. American Thoracic Society. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107-1136 14. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flowmediated dilation. Hypertension 2010;55:1075-1085 15. Yeboah J, Folsom AR, Burke GL, et al. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 2009;120:502-509 16. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 2007;115:2390-2397 17. Fraser KL, Tullis DE, Sasson Z, et al. Pulmonary hypertension and cardiac function in adult cystic fibrosis: role of hypoxemia. Chest 1999;115:1321-1328 18. Perrin FM, Serino W. Ischaemic heart disease--a new issue in cystic fibrosis? J R Soc Med 2010;103 Suppl 1:S44-48 19. Robert R, Thoreau V, Norez C, et al. Regulation of the cystic fibrosis transmembrane conductance regulator channel by beta-adrenergic agonists and vasoactive intestinal peptide in rat smooth muscle cells and its role in vasorelaxation. J Biol Chem 2004;279:21160-21168 20. Michoud MC, Robert R, Hassan M, et al. Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle. Am J Respir Cell Mol Biol 2009;40:217-222 21. Tousson A, Van Tine BA, Naren AP, Shaw GM, Schwiebert LM. Characterization of CFTR expression and chloride channel activity in human endothelia. Am J Physiol 1998;275:C1555-1564 22. McKone EF, Goss CH, Aitken ML. CFTR genotype as a predictor of prognosis in cystic fibrosis. Chest 2006;130:1441-1447 23. Wood LG, Fitzgerald DA, Gibson PG, et al. Oxidative stress in cystic fibrosis: dietary and metabolic factors. J Am Coll Nutr 2001;20:157-165 24. Elizur A, Cannon CL, Ferkol TW. Airway inflammation in cystic fibrosis. Chest 2008;133:489-495 25. Acevedo M, Arnaiz P, Barja S, et al. [Relationship of C-reactive protein to adiposity, cardiovascular risk factors and subclinical atherosclerosis in healthy children]. Rev Esp Cardiol 2007;60:1051-1058 26. Ridker PM, Cook N. Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores. Circulation 2004;109:1955- 1959 27. Holmes MV, Jiang B, McNeill K, et al. Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. PLoS One 2010;5:e10242 28. Barr RG, Mesia-Vela S, Austin JH, et al. Impaired Flow-mediated Dilation is Associated with Low Pulmonary Function and Emphysema in Ex-smokers. Am J Respir Crit Care Med 2007;176:1200-1207 29. Eickhoff P, Valipour A, Kiss D, et al. Determinants of systemic vascular function in patients with stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;178:1211-1218 30. Moro L, Pedone C, Scarlata S, et al. Endothelial dysfunction in chronic obstructive pulmonary disease. Angiology 2008;59:357-364 31. Orenstein DM, Franklin BA, Doershuk CF, et al. Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program. Chest 1981;80:392-398 32. Salh W, Bilton D, Dodd M, Webb AK. Effect of exercise and physiotherapy in aiding sputum expectoration in adults with cystic fibrosis. Thorax 1989;44:1006-1008 33. Schneiderman-Walker J, Pollock SL, Corey M, et al. A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. J Pediatr 2000;136:304-310 34. Huang B, Brennan KM, Budinger TF, Maltz JS. Assessment of endothelial function in the radial artery using inhaled albuterol. Conf Proc IEEE Eng Med Biol Soc 2007;2007:3629-3631",
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    Poore, S, Berry, B, Eidson, D, McKie, KT & Harris, R 2013, 'Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis', Chest, vol. 143, no. 4, pp. 939-946.

    Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis. / Poore, Spencer; Berry, Breanna; Eidson, Dabney; McKie, Katie T; Harris, Ryan.

    In: Chest, Vol. 143, No. 4, 04.2013, p. 939-946.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis

    AU - Poore, Spencer

    AU - Berry, Breanna

    AU - Eidson, Dabney

    AU - McKie, Katie T

    AU - Harris, Ryan

    N1 - Reference text: 1. Green D. Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J Appl Physiol 2005;99:1233-1234; discussion 1237-1238 2. Uehata A, Lieberman EH, Gerhard MD, et al. Noninvasive assessment of endotheliumdependent flow-mediated dilation of the brachial artery. Vascular Medicine 1997;2:87-92 3. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-1115 4. Peinado VI, Barbera JA, Ramirez J, et al. Endothelial dysfunction in pulmonary arteries of patients with mild COPD. Am J Physiol 1998;274:L908-913 5. Johnstone MT, Creager MA, Scales KM. Impaired endothelium-dependent vasodilation in patients with insuline-dependent diabetes mellitus. Circulation 1993;88:2510-2516 6. Maiorana A, O'Droscoll F, Taylor R, Green D. Exercise and the Nitric Oxide Vasodilator System. Sports Med 2003;33:1013-1035 7. Edwards DG, Schofield RS, Lennon SL, et al. Effect of exercise training on endothelial function in men with coronary artery disease. Am J Cardiol 2004;93:617-620 8. Guerci B, Kearney-Schwartz A, Bohme P, Zannad F, Drouin P. Endothelial dysfunction and type 2 diabetes. Part 1: physiology and methods for exploring the endothelial function. Diabetes Metab 2001;27:425-434 9. Wolff B, Lodziewski S, Bollmann T, Opitz CF, Ewert R. Impaired peripheral endothelial function in severe idiopathic pulmonary hypertension correlates with the pulmonary vascular response to inhaled iloprost. Am Heart J 2007;153:1088 e1081-1087 10. Dinh Xuan AT, Higenbottam TW, Pepke-Zaba J, Clelland C, Wallwork J. Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries. Eur J Pharmacol 1989;163:401-403 11. Henno P, Maurey C, Danel C, et al. Pulmonary vascular dysfunction in end-stage cystic fibrosis: role of NF-kappaB and endothelin-1. Eur Respir J 2009;34:1329-1337 12. Romano M, Collura M, Lapichino L, et al. Endothelial perturbation in cystic fibrosis. Thromb Haemost 2001;86:1363-1367 13. American Thoracic Society. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107-1136 14. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flowmediated dilation. Hypertension 2010;55:1075-1085 15. Yeboah J, Folsom AR, Burke GL, et al. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 2009;120:502-509 16. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 2007;115:2390-2397 17. Fraser KL, Tullis DE, Sasson Z, et al. Pulmonary hypertension and cardiac function in adult cystic fibrosis: role of hypoxemia. Chest 1999;115:1321-1328 18. Perrin FM, Serino W. Ischaemic heart disease--a new issue in cystic fibrosis? J R Soc Med 2010;103 Suppl 1:S44-48 19. Robert R, Thoreau V, Norez C, et al. Regulation of the cystic fibrosis transmembrane conductance regulator channel by beta-adrenergic agonists and vasoactive intestinal peptide in rat smooth muscle cells and its role in vasorelaxation. J Biol Chem 2004;279:21160-21168 20. Michoud MC, Robert R, Hassan M, et al. Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle. Am J Respir Cell Mol Biol 2009;40:217-222 21. Tousson A, Van Tine BA, Naren AP, Shaw GM, Schwiebert LM. Characterization of CFTR expression and chloride channel activity in human endothelia. Am J Physiol 1998;275:C1555-1564 22. McKone EF, Goss CH, Aitken ML. CFTR genotype as a predictor of prognosis in cystic fibrosis. Chest 2006;130:1441-1447 23. Wood LG, Fitzgerald DA, Gibson PG, et al. Oxidative stress in cystic fibrosis: dietary and metabolic factors. J Am Coll Nutr 2001;20:157-165 24. Elizur A, Cannon CL, Ferkol TW. Airway inflammation in cystic fibrosis. Chest 2008;133:489-495 25. Acevedo M, Arnaiz P, Barja S, et al. [Relationship of C-reactive protein to adiposity, cardiovascular risk factors and subclinical atherosclerosis in healthy children]. Rev Esp Cardiol 2007;60:1051-1058 26. Ridker PM, Cook N. Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores. Circulation 2004;109:1955- 1959 27. Holmes MV, Jiang B, McNeill K, et al. Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. PLoS One 2010;5:e10242 28. Barr RG, Mesia-Vela S, Austin JH, et al. Impaired Flow-mediated Dilation is Associated with Low Pulmonary Function and Emphysema in Ex-smokers. Am J Respir Crit Care Med 2007;176:1200-1207 29. Eickhoff P, Valipour A, Kiss D, et al. Determinants of systemic vascular function in patients with stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;178:1211-1218 30. Moro L, Pedone C, Scarlata S, et al. Endothelial dysfunction in chronic obstructive pulmonary disease. Angiology 2008;59:357-364 31. Orenstein DM, Franklin BA, Doershuk CF, et al. Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program. Chest 1981;80:392-398 32. Salh W, Bilton D, Dodd M, Webb AK. Effect of exercise and physiotherapy in aiding sputum expectoration in adults with cystic fibrosis. Thorax 1989;44:1006-1008 33. Schneiderman-Walker J, Pollock SL, Corey M, et al. A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. J Pediatr 2000;136:304-310 34. Huang B, Brennan KM, Budinger TF, Maltz JS. Assessment of endothelial function in the radial artery using inhaled albuterol. Conf Proc IEEE Eng Med Biol Soc 2007;2007:3629-3631

    PY - 2013/4

    Y1 - 2013/4

    N2 - Background: Cystic fibrosis (CF) is a genetic disorder that affects not only pulmonary function, but also multiple organ systems. The flow-mediated dilation (FMD) test is a non-invasive assessment of endothelial function and nitric oxide bioavailability. Thus, the purpose of this study was to determine if 1) endothelial dysfunction is present in young patients with CF, and 2) endothelial function is associated with pulmonary function and exercise capacity.Methods: 15 patients with CF and 15 demographically matched controls participated in this study. Spirometry, brachial artery FMD, and a maximal exercise capacity test on a cycle ergometer were performed on all subjects to determine pulmonary function, endothelial function, and exercise capacity, respectively.Results: No differences (p>0.05) in age, height, or BMI were observed between patients withCF and controls. FEV1 (% predicted), FEV1/FVC, and FEF25-75 were lower in patients with CF.VO2 peak (absolute and relative) was similar between groups; however, VO2 (% predicted andml/kg fat free mass/min) and peak workload were significantly (p

    AB - Background: Cystic fibrosis (CF) is a genetic disorder that affects not only pulmonary function, but also multiple organ systems. The flow-mediated dilation (FMD) test is a non-invasive assessment of endothelial function and nitric oxide bioavailability. Thus, the purpose of this study was to determine if 1) endothelial dysfunction is present in young patients with CF, and 2) endothelial function is associated with pulmonary function and exercise capacity.Methods: 15 patients with CF and 15 demographically matched controls participated in this study. Spirometry, brachial artery FMD, and a maximal exercise capacity test on a cycle ergometer were performed on all subjects to determine pulmonary function, endothelial function, and exercise capacity, respectively.Results: No differences (p>0.05) in age, height, or BMI were observed between patients withCF and controls. FEV1 (% predicted), FEV1/FVC, and FEF25-75 were lower in patients with CF.VO2 peak (absolute and relative) was similar between groups; however, VO2 (% predicted andml/kg fat free mass/min) and peak workload were significantly (p

    M3 - Article

    VL - 143

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    JO - Chest

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    SN - 0012-3692

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    Poore S, Berry B, Eidson D, McKie KT, Harris R. Evidence of Vascular Endothelial Dysfunction in Young Patienrts with Cystic Fibrosis. Chest. 2013 Apr;143(4):939-946.