Abstract
Chitosan nanoparticle delivery systems have potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against both P. aeruginosa and MRSA, with zones of inhibition ranging from 13 to 24 mm and complete reduction in colony forming units observed between 3 to 24 hours. These chitosan nanoparticle formulations loaded with antimicrobials hold promise for addressing orthopedic complications.
| Original language | English |
|---|---|
| Article number | 208 |
| Number of pages | 14 |
| Journal | Antibiotics |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published (in print/issue) - 22 Feb 2024 |
Bibliographical note
Publisher Copyright:© 2024 by the authors.
Data Access Statement
The authors confirm that the data supporting the findings of this study are available within the article.Keywords
- Nanoparticles
- chitosan
- osteomyelitis
- drug delivery
- antimicrobials
- gentamicin
- nanoparticles
