Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor.

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Abstract

The insulinotropic properties of zebrafish GIP (zfGIP) were assessed in vitro using clonal pancreatic β-cell lines and isolated mouse islets and acute effects on glucose tolerance and insulin release in vivo were evaluated in mice. The peptide produced a dose-dependent increase in the rate of insulin release from BRIN-BD11 rat clonal β-cells at concentrations ≥30nM. Insulin release from 1.1 B4 human clonal β-cells and mouse islets was significantly increased by zfGIP (10nM and 1μM). The in vitro insulinotropic activity of zfGIP was decreased after incubating BRIN-BD11 cells with the GLP-1 receptor antagonist, exendin-4(9-39) (p
Original languageEnglish
Pages (from-to)182-189
JournalPeptides
Volume100
Early online date20 Nov 2017
DOIs
Publication statusE-pub ahead of print - 20 Nov 2017

Keywords

  • Type 2 diabetes
  • Zebrafish
  • GIP
  • GLP-1
  • Glucagon
  • Evolution

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