Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay

Aine McKillop, MH Mooney, P Harriott, Peter Flatt, Finbarr O'Harte

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immuno. cytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/-0.04 ng/ml and 2.20 +/-0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, respectively. The concentration of glycated insulin was elevated 22-fold in obese mice compared to controls (P
Original languageEnglish
Pages (from-to)524-528
JournalBiochemical and Biophysical Research Communications
Volume286
Issue number3
Publication statusPublished - Aug 2001

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