Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay

Aine McKillop; MH Mooney; P Harriott; Peter Flatt; Finbarr O'Harte

Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay

Aine McKillop, MH Mooney, P Harriott, Peter Flatt, Finbarr O'Harte

Research output: Contribution to journal › Article › peer-review

Abstract

Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immuno. cytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/-0.04 ng/ml and 2.20 +/-0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, respectively. The concentration of glycated insulin was elevated 22-fold in obese mice compared to controls (P

Original language	English
Pages (from-to)	524-528
Journal	Biochemical and Biophysical Research Communications
Volume	286
Issue number	3
Publication status	Published (in print/issue) - Aug 2001

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title = "Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay",

abstract = "Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immuno. cytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/-0.04 ng/ml and 2.20 +/-0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, respectively. The concentration of glycated insulin was elevated 22-fold in obese mice compared to controls (P",

author = "Aine McKillop and MH Mooney and P Harriott and Peter Flatt and Finbarr O'Harte",

year = "2001",

month = aug,

language = "English",

volume = "286",

pages = "524--528",

journal = "Biochemical and Biophysical Research Communications",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay

AU - McKillop, Aine

AU - Mooney, MH

AU - Harriott, P

AU - Flatt, Peter

AU - O'Harte, Finbarr

PY - 2001/8

Y1 - 2001/8

N2 - Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immuno. cytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/-0.04 ng/ml and 2.20 +/-0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, respectively. The concentration of glycated insulin was elevated 22-fold in obese mice compared to controls (P

AB - Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immuno. cytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/-0.04 ng/ml and 2.20 +/-0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, respectively. The concentration of glycated insulin was elevated 22-fold in obese mice compared to controls (P

M3 - Article

VL - 286

SP - 524

EP - 528

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay

Abstract

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