Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immuno. cytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/-0.04 ng/ml and 2.20 +/-0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, respectively. The concentration of glycated insulin was elevated 22-fold in obese mice compared to controls (P
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Aug 2001|
McKillop, A., Mooney, MH., Harriott, P., Flatt, P., & O'Harte, F. (2001). Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay. Biochemical and Biophysical Research Communications, 286(3), 524-528.