European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe

Garne Ester; Maria Loane; Joachim Tan; Elisa Ballardini,; Joanna  Brigden; Clara Cavero-Carbonell; Alessio Coi; Mads  Damkjær; Laura Garcia-Villodre; Mika  Gissler; Joanne Given; Anna  Heino; Sue Jordan; Elizabeth Limb; Amanda Neville; Anke Rissmann; Michele Santoro; Ieuan  Scanlon; Stine  Kjær Urhøj; Diana Wellesley; Joan Morris

doi:10.1111/apa.16726

European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe

Garne Ester, Maria Loane, Joachim Tan, Elisa Ballardini,, Joanna Brigden, Clara Cavero-Carbonell, Alessio Coi, Mads Damkjær, Laura Garcia-Villodre, Mika Gissler, Joanne Given, Anna Heino, Sue Jordan, Elizabeth Limb, Amanda Neville, Anke Rissmann, Michele Santoro, Ieuan Scanlon, Stine Kjær Urhøj, Diana WellesleyJoan Morris

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Abstract

AIM: Children with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.

METHODS: A population-based record-linkage study in Finland, Wales and regions of Denmark, England, Italy and Spain. A total of 91 504 children with congenital anomalies born in 1995-2014 were followed to their tenth birthday or the end of 2015. Electronic linkage to hospital databases provided data on inpatient surgical procedures and meta-analyses of surgical procedures were performed by age groups.

RESULTS: The percentage of children having surgery in the first year was 38% with some differences across regions and 14% also underwent surgery at age 1-4 years. Regional differences in age at the time of their first surgical procedure were observed for children with cleft palate, hydronephrosis, hypospadias, clubfoot and craniosynostosis. The children had a median of 2.0 (95% CI 1.98, 2.02) surgical procedures before age 5 years with children with oesophageal atresia having the highest median number of procedures (4.5; 95% CI 3.3, 5.8).

CONCLUSION: A third of children with congenital anomalies required surgery during infancy and often more than one procedure was needed before age 5 years. There was no European consensus on the preferred age for surgery for some anomalies.

Original language	English
Pages (from-to)	1304-1311
Number of pages	8
Journal	Acta Paediatrica
Volume	112
Issue number	6
Early online date	23 Feb 2023
DOIs	https://doi.org/10.1111/apa.16726
Publication status	Published (in print/issue) - 1 Jun 2023

Bibliographical note

Funding Information:
This project was funded by the European Union's Horizon 2020 research and innovation programme (Grant agreement number 733001). The funders played no role in the study or paper.

Publisher Copyright:
© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

Keywords

congenital anomaly
median age
paediatric surgery
population-based record-linkage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Ester, G., Loane, M., Tan, J., Ballardini, E., Brigden, J., Cavero-Carbonell, C., Coi, A., Damkjær, M., Garcia-Villodre, L., Gissler, M., Given, J., Heino, A., Jordan, S., Limb, E., Neville, A., Rissmann, A., Santoro, M., Scanlon, I., Kjær Urhøj, S., ... Morris, J. (2023). European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe. Acta Paediatrica, 112(6), 1304-1311. https://doi.org/10.1111/apa.16726

@article{79dfea377b3e4b9e8baae2737b1fce45,

title = "European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe",

abstract = "AIM: Children with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.METHODS: A population-based record-linkage study in Finland, Wales and regions of Denmark, England, Italy and Spain. A total of 91 504 children with congenital anomalies born in 1995-2014 were followed to their tenth birthday or the end of 2015. Electronic linkage to hospital databases provided data on inpatient surgical procedures and meta-analyses of surgical procedures were performed by age groups.RESULTS: The percentage of children having surgery in the first year was 38% with some differences across regions and 14% also underwent surgery at age 1-4 years. Regional differences in age at the time of their first surgical procedure were observed for children with cleft palate, hydronephrosis, hypospadias, clubfoot and craniosynostosis. The children had a median of 2.0 (95% CI 1.98, 2.02) surgical procedures before age 5 years with children with oesophageal atresia having the highest median number of procedures (4.5; 95% CI 3.3, 5.8).CONCLUSION: A third of children with congenital anomalies required surgery during infancy and often more than one procedure was needed before age 5 years. There was no European consensus on the preferred age for surgery for some anomalies.",

keywords = "congenital anomaly, median age, paediatric surgery, population-based record-linkage",

author = "Garne Ester and Maria Loane and Joachim Tan and Elisa Ballardini, and Joanna Brigden and Clara Cavero-Carbonell and Alessio Coi and Mads Damkj{\ae}r and Laura Garcia-Villodre and Mika Gissler and Joanne Given and Anna Heino and Sue Jordan and Elizabeth Limb and Amanda Neville and Anke Rissmann and Michele Santoro and Ieuan Scanlon and {Kj{\ae}r Urh{\o}j}, Stine and Diana Wellesley and Joan Morris",

note = "Funding Information: This project was funded by the European Union's Horizon 2020 research and innovation programme (Grant agreement number 733001). The funders played no role in the study or paper. Publisher Copyright: {\textcopyright} 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.",

year = "2023",

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doi = "10.1111/apa.16726",

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Ester, G, Loane, M, Tan, J, Ballardini, E, Brigden, J, Cavero-Carbonell, C, Coi, A, Damkjær, M, Garcia-Villodre, L, Gissler, M, Given, J, Heino, A, Jordan, S, Limb, E, Neville, A, Rissmann, A, Santoro, M, Scanlon, I, Kjær Urhøj, S, Wellesley, D & Morris, J 2023, 'European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe', Acta Paediatrica, vol. 112, no. 6, pp. 1304-1311. https://doi.org/10.1111/apa.16726

TY - JOUR

T1 - European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe

AU - Ester, Garne

AU - Loane, Maria

AU - Tan, Joachim

AU - Ballardini,, Elisa

AU - Brigden, Joanna

AU - Cavero-Carbonell, Clara

AU - Coi, Alessio

AU - Damkjær, Mads

AU - Garcia-Villodre, Laura

AU - Gissler, Mika

AU - Given, Joanne

AU - Heino, Anna

AU - Jordan, Sue

AU - Limb, Elizabeth

AU - Neville, Amanda

AU - Rissmann, Anke

AU - Santoro, Michele

AU - Scanlon, Ieuan

AU - Kjær Urhøj, Stine

AU - Wellesley, Diana

AU - Morris, Joan

N1 - Funding Information: This project was funded by the European Union's Horizon 2020 research and innovation programme (Grant agreement number 733001). The funders played no role in the study or paper. Publisher Copyright: © 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - AIM: Children with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.METHODS: A population-based record-linkage study in Finland, Wales and regions of Denmark, England, Italy and Spain. A total of 91 504 children with congenital anomalies born in 1995-2014 were followed to their tenth birthday or the end of 2015. Electronic linkage to hospital databases provided data on inpatient surgical procedures and meta-analyses of surgical procedures were performed by age groups.RESULTS: The percentage of children having surgery in the first year was 38% with some differences across regions and 14% also underwent surgery at age 1-4 years. Regional differences in age at the time of their first surgical procedure were observed for children with cleft palate, hydronephrosis, hypospadias, clubfoot and craniosynostosis. The children had a median of 2.0 (95% CI 1.98, 2.02) surgical procedures before age 5 years with children with oesophageal atresia having the highest median number of procedures (4.5; 95% CI 3.3, 5.8).CONCLUSION: A third of children with congenital anomalies required surgery during infancy and often more than one procedure was needed before age 5 years. There was no European consensus on the preferred age for surgery for some anomalies.

AB - AIM: Children with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.METHODS: A population-based record-linkage study in Finland, Wales and regions of Denmark, England, Italy and Spain. A total of 91 504 children with congenital anomalies born in 1995-2014 were followed to their tenth birthday or the end of 2015. Electronic linkage to hospital databases provided data on inpatient surgical procedures and meta-analyses of surgical procedures were performed by age groups.RESULTS: The percentage of children having surgery in the first year was 38% with some differences across regions and 14% also underwent surgery at age 1-4 years. Regional differences in age at the time of their first surgical procedure were observed for children with cleft palate, hydronephrosis, hypospadias, clubfoot and craniosynostosis. The children had a median of 2.0 (95% CI 1.98, 2.02) surgical procedures before age 5 years with children with oesophageal atresia having the highest median number of procedures (4.5; 95% CI 3.3, 5.8).CONCLUSION: A third of children with congenital anomalies required surgery during infancy and often more than one procedure was needed before age 5 years. There was no European consensus on the preferred age for surgery for some anomalies.

KW - congenital anomaly

KW - median age

KW - paediatric surgery

KW - population-based record-linkage

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U2 - 10.1111/apa.16726

DO - 10.1111/apa.16726

M3 - Article

C2 - 36823678

SN - 0803-5253

VL - 112

SP - 1304

EP - 1311

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 6

ER -

European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe

Abstract

Bibliographical note

Keywords

UN SDGs

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