Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach

Angela  Hassiotis; Craig  Melville; Andrew  Jahoda; Andre  Strydom; Sally Ann Cooper; Laurence Taggart; Vivien  Cooper; Elizabeth  Steed; Afia Ali; Rachel  Hunter; Farah Elahi; Umesh  Chauhan; Penny  Rapaport; Louise Marston

doi:10.1016/j.ridd.2022.104202

Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach

Angela Hassiotis , Craig Melville, Andrew Jahoda , Andre Strydom , Sally Ann Cooper , Laurence Taggart, Vivien Cooper , Elizabeth Steed, Afia Ali, Rachel Hunter , Farah Elahi, Umesh Chauhan , Penny Rapaport, Louise Marston

Research output: Contribution to journal › Article › peer-review

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Abstract

Background
The minimal clinically important difference (MCID) is relevant in the estimation of improvement in a patient outcome.

Aim
To determine the MCID on the Aberrant Behaviour Checklist–Irritability (ABC-I), widely used to measure the effects of intervention for aggressive challenging behaviour in people with intellectual disabilities.

Method and Procedures
We utilised distribution and anchor based methods to estimate the ABC-I MCID. We extracted data from 15 randomised controlled trials (RCTs) for meta-analysis. We conducted three online workshops with family carers and professionals to consider meaningful change in case vignettes of increasing severity of aggressive challenging behaviour.

Outcomes and Results
We did not find overlap in the range of values between the two approaches. The meta-analysis indicated a range of MCID on the ABC-I (0.05, 4.94) whilst the anchor-based estimation indicated a larger change (6.6, 16.6).

Conclusions and Implications
The MCID is essential in interpreting the results from intervention studies. The present work was undertaken as part of a wider programme on the development and testing of a psychosocial intervention for aggressive challenging behaviour, and it is of interest to researchers in justifying how they choose and determine the MCID on the outcome of interest.

Original language	English
Article number	104202
Number of pages	10
Journal	Research in Developmental Disabilities
Volume	124
Early online date	3 Mar 2022
DOIs	https://doi.org/10.1016/j.ridd.2022.104202
Publication status	Published (in print/issue) - 31 May 2022

Bibliographical note

Funding Information:
The PETAL programme is funded by the National Institute for Health Research (NIHR) [PGfAR NIHR200120]. The views expressed within the manuscript are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

MCID
RCT
Intellectual Disabilities
Clinical trials
Aggressive challenging behaviour
Caregivers
Aggression
Humans
Checklist
Minimal Clinically Important Difference
Intellectual Disability

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Hassiotis , A., Melville, C., Jahoda , A., Strydom , A., Cooper , S. A., Taggart, L., Cooper , V., Steed, E., Ali, A., Hunter , R., Elahi, F., Chauhan , U., Rapaport, P., & Marston, L. (2022). Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach. Research in Developmental Disabilities, 124, Article 104202. https://doi.org/10.1016/j.ridd.2022.104202

@article{5330207fd8a0414c984e53351d80f840,

title = "Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach",

abstract = "Background The minimal clinically important difference (MCID) is relevant in the estimation of improvement in a patient outcome. AimTo determine the MCID on the Aberrant Behaviour Checklist–Irritability (ABC-I), widely used to measure the effects of intervention for aggressive challenging behaviour in people with intellectual disabilities. Method and Procedures We utilised distribution and anchor based methods to estimate the ABC-I MCID. We extracted data from 15 randomised controlled trials (RCTs) for meta-analysis. We conducted three online workshops with family carers and professionals to consider meaningful change in case vignettes of increasing severity of aggressive challenging behaviour. Outcomes and Results We did not find overlap in the range of values between the two approaches. The meta-analysis indicated a range of MCID on the ABC-I (0.05, 4.94) whilst the anchor-based estimation indicated a larger change (6.6, 16.6). Conclusions and ImplicationsThe MCID is essential in interpreting the results from intervention studies. The present work was undertaken as part of a wider programme on the development and testing of a psychosocial intervention for aggressive challenging behaviour, and it is of interest to researchers in justifying how they choose and determine the MCID on the outcome of interest. ",

keywords = "MCID, RCT, Intellectual Disabilities, Clinical trials, Aggressive challenging behaviour, Caregivers, Aggression, Humans, Checklist, Minimal Clinically Important Difference, Intellectual Disability",

author = "Angela Hassiotis and Craig Melville and Andrew Jahoda and Andre Strydom and Cooper, {Sally Ann} and Laurence Taggart and Vivien Cooper and Elizabeth Steed and Afia Ali and Rachel Hunter and Farah Elahi and Umesh Chauhan and Penny Rapaport and Louise Marston",

note = "Funding Information: The PETAL programme is funded by the National Institute for Health Research (NIHR) [PGfAR NIHR200120]. The views expressed within the manuscript are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = may,

day = "31",

doi = "10.1016/j.ridd.2022.104202",

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Hassiotis , A, Melville, C, Jahoda , A, Strydom , A, Cooper , SA, Taggart, L, Cooper , V, Steed, E, Ali, A, Hunter , R, Elahi, F, Chauhan , U, Rapaport, P & Marston, L 2022, 'Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach', Research in Developmental Disabilities, vol. 124, 104202. https://doi.org/10.1016/j.ridd.2022.104202

Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach. / Hassiotis , Angela ; Melville, Craig ; Jahoda , Andrew et al.
In: Research in Developmental Disabilities, Vol. 124, 104202, 31.05.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach

AU - Hassiotis , Angela

AU - Melville, Craig

AU - Jahoda , Andrew

AU - Strydom , Andre

AU - Cooper , Sally Ann

AU - Taggart, Laurence

AU - Cooper , Vivien

AU - Steed, Elizabeth

AU - Ali, Afia

AU - Hunter , Rachel

AU - Elahi, Farah

AU - Chauhan , Umesh

AU - Rapaport, Penny

AU - Marston, Louise

N1 - Funding Information: The PETAL programme is funded by the National Institute for Health Research (NIHR) [PGfAR NIHR200120]. The views expressed within the manuscript are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/5/31

Y1 - 2022/5/31

N2 - Background The minimal clinically important difference (MCID) is relevant in the estimation of improvement in a patient outcome. AimTo determine the MCID on the Aberrant Behaviour Checklist–Irritability (ABC-I), widely used to measure the effects of intervention for aggressive challenging behaviour in people with intellectual disabilities. Method and Procedures We utilised distribution and anchor based methods to estimate the ABC-I MCID. We extracted data from 15 randomised controlled trials (RCTs) for meta-analysis. We conducted three online workshops with family carers and professionals to consider meaningful change in case vignettes of increasing severity of aggressive challenging behaviour. Outcomes and Results We did not find overlap in the range of values between the two approaches. The meta-analysis indicated a range of MCID on the ABC-I (0.05, 4.94) whilst the anchor-based estimation indicated a larger change (6.6, 16.6). Conclusions and ImplicationsThe MCID is essential in interpreting the results from intervention studies. The present work was undertaken as part of a wider programme on the development and testing of a psychosocial intervention for aggressive challenging behaviour, and it is of interest to researchers in justifying how they choose and determine the MCID on the outcome of interest.

AB - Background The minimal clinically important difference (MCID) is relevant in the estimation of improvement in a patient outcome. AimTo determine the MCID on the Aberrant Behaviour Checklist–Irritability (ABC-I), widely used to measure the effects of intervention for aggressive challenging behaviour in people with intellectual disabilities. Method and Procedures We utilised distribution and anchor based methods to estimate the ABC-I MCID. We extracted data from 15 randomised controlled trials (RCTs) for meta-analysis. We conducted three online workshops with family carers and professionals to consider meaningful change in case vignettes of increasing severity of aggressive challenging behaviour. Outcomes and Results We did not find overlap in the range of values between the two approaches. The meta-analysis indicated a range of MCID on the ABC-I (0.05, 4.94) whilst the anchor-based estimation indicated a larger change (6.6, 16.6). Conclusions and ImplicationsThe MCID is essential in interpreting the results from intervention studies. The present work was undertaken as part of a wider programme on the development and testing of a psychosocial intervention for aggressive challenging behaviour, and it is of interest to researchers in justifying how they choose and determine the MCID on the outcome of interest.

KW - MCID

KW - RCT

KW - Intellectual Disabilities

KW - Clinical trials

KW - Aggressive challenging behaviour

KW - Caregivers

KW - Aggression

KW - Humans

KW - Checklist

KW - Minimal Clinically Important Difference

KW - Intellectual Disability

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DO - 10.1016/j.ridd.2022.104202

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JO - Research in Developmental Disabilities

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Hassiotis A, Melville C, Jahoda A, Strydom A, Cooper SA, Taggart L et al. Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach. Research in Developmental Disabilities. 2022 May 31;124:104202. Epub 2022 Mar 3. doi: 10.1016/j.ridd.2022.104202

Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach

Abstract

Bibliographical note

Keywords

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