Estimation of the minimal clinically important difference on the Aberrant Behaviour Checklist–Irritability (ABC-I) for people with intellectual disabilities who display aggressive challenging behaviour: A triangulated approach

Angela Hassiotis , Craig Melville, Andrew Jahoda , Andre Strydom , Sally Ann Cooper , Laurence Taggart, Vivien Cooper , Elizabeth Steed, Afia Ali, Rachel Hunter , Farah Elahi, Umesh Chauhan , Penny Rapaport, Louise Marston

Research output: Contribution to journalArticlepeer-review

Abstract

Background
The minimal clinically important difference (MCID) is relevant in the estimation of improvement in a patient outcome.

Aim
To determine the MCID on the Aberrant Behaviour Checklist–Irritability (ABC-I), widely used to measure the effects of intervention for aggressive challenging behaviour in people with intellectual disabilities.

Method and Procedures
We utilised distribution and anchor based methods to estimate the ABC-I MCID. We extracted data from 15 randomised controlled trials (RCTs) for meta-analysis. We conducted three online workshops with family carers and professionals to consider meaningful change in case vignettes of increasing severity of aggressive challenging behaviour.

Outcomes and Results
We did not find overlap in the range of values between the two approaches. The meta-analysis indicated a range of MCID on the ABC-I (0.05, 4.94) whilst the anchor-based estimation indicated a larger change (6.6, 16.6).

Conclusions and Implications
The MCID is essential in interpreting the results from intervention studies. The present work was undertaken as part of a wider programme on the development and testing of a psychosocial intervention for aggressive challenging behaviour, and it is of interest to researchers in justifying how they choose and determine the MCID on the outcome of interest.
Original languageEnglish
Article number104202
Pages (from-to)1-10
Number of pages10
JournalResearch in Developmental Disabilities
Volume124
Early online date3 Mar 2022
DOIs
Publication statusE-pub ahead of print - 3 Mar 2022

Bibliographical note

Funding Information:
The PETAL programme is funded by the National Institute for Health Research (NIHR) [PGfAR NIHR200120]. The views expressed within the manuscript are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • MCID
  • RCT
  • Intellectual Disabilities
  • Clinical trials
  • Aggressive challenging behaviour

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