Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH

A Polito, F Intorre, M Andriollo-Sanchez, E Azzini, A Raguzzini, N Meunier, V Ducros, JM O'Connor, C Coudray, AM Roussel, G Maiani

Research output: Contribution to journalArticle

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Abstract

Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.
LanguageEnglish
PagesS42-S47
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue numberSuppl.
DOIs
Publication statusPublished - Nov 2005

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Folic Acid
Zinc
Erythrocytes
Vitamin A
Vitamins
France
Volunteers
Avitaminosis
Food
Northern Ireland
Tocopherols
Micronutrients
alpha-Tocopherol
Luminescence
Immunoassay
Italy
Fasting
Age Groups
Fats
Prospective Studies

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Polito, A., Intorre, F., Andriollo-Sanchez, M., Azzini, E., Raguzzini, A., Meunier, N., ... Maiani, G. (2005). Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. European Journal of Clinical Nutrition, 59(Suppl.), S42-S47. https://doi.org/10.1038/sj.ejcn.1602297
Polito, A ; Intorre, F ; Andriollo-Sanchez, M ; Azzini, E ; Raguzzini, A ; Meunier, N ; Ducros, V ; O'Connor, JM ; Coudray, C ; Roussel, AM ; Maiani, G. / Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. In: European Journal of Clinical Nutrition. 2005 ; Vol. 59, No. Suppl. pp. S42-S47.
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abstract = "Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40{\%} of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.",
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Polito, A, Intorre, F, Andriollo-Sanchez, M, Azzini, E, Raguzzini, A, Meunier, N, Ducros, V, O'Connor, JM, Coudray, C, Roussel, AM & Maiani, G 2005, 'Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH', European Journal of Clinical Nutrition, vol. 59, no. Suppl., pp. S42-S47. https://doi.org/10.1038/sj.ejcn.1602297

Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. / Polito, A; Intorre, F; Andriollo-Sanchez, M; Azzini, E; Raguzzini, A; Meunier, N; Ducros, V; O'Connor, JM; Coudray, C; Roussel, AM; Maiani, G.

In: European Journal of Clinical Nutrition, Vol. 59, No. Suppl., 11.2005, p. S42-S47.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH

AU - Polito, A

AU - Intorre, F

AU - Andriollo-Sanchez, M

AU - Azzini, E

AU - Raguzzini, A

AU - Meunier, N

AU - Ducros, V

AU - O'Connor, JM

AU - Coudray, C

AU - Roussel, AM

AU - Maiani, G

PY - 2005/11

Y1 - 2005/11

N2 - Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.

AB - Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.

U2 - 10.1038/sj.ejcn.1602297

DO - 10.1038/sj.ejcn.1602297

M3 - Article

VL - 59

SP - S42-S47

JO - European Journal of Clinical Nutrition

T2 - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - Suppl.

ER -