Enhancing the sensitivity of point-of-care cardiac marker detection using interdigitated impedimetric immunosensor arrays

Electrical impedance spectroscopy (EIS) measures the electrical impedance (Z) at an interface as a function of AC frequency. The application of a constant low amplitude DC bias avoids disturbance of the probe layer.The major advantage of impedimetric biosensors over most other types is their ability to perform label free detection [1]. EIS also enables detection of target-probe binding in real time which can improve measurement accuracy and understanding of the biological process.The aim of this work was to examine the influence of interdigitated electrode gap size on EIS sensitivity for application in point-of-care cardiac marker analysis.