Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Bridgeen McCaughan; C Rouanet; Colin Fowley; N Nomikou; Anthony McHale; John Callan

doi:10.1016/j.bmcl.2011.08.015

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Bridgeen McCaughan
, C Rouanet
, Colin Fowley
, N Nomikou
, Anthony McHale
, John Callan

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

Original language	English
Pages (from-to)	5750-5752
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2011.08.015
Publication status	Published (in print/issue) - 1 Oct 2011

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10.1016/j.bmcl.2011.08.015

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title = "Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.",

abstract = "A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.",

author = "Bridgeen McCaughan and C Rouanet and Colin Fowley and N Nomikou and Anthony McHale and John Callan",

year = "2011",

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doi = "10.1016/j.bmcl.2011.08.015",

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AU - McCaughan, Bridgeen

AU - Rouanet, C

AU - Fowley, Colin

AU - Nomikou, N

AU - McHale, Anthony

AU - Callan, John

PY - 2011/10/1

Y1 - 2011/10/1

N2 - A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

AB - A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

U2 - 10.1016/j.bmcl.2011.08.015

DO - 10.1016/j.bmcl.2011.08.015

M3 - Article

VL - 21

SP - 5750

EP - 5752

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Abstract

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