Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Bridgeen McCaughan, C Rouanet, Colin Fowley, N Nomikou, Anthony McHale, John Callan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.
LanguageEnglish
Pages5750-5752
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number19
DOIs
Publication statusPublished - 1 Oct 2011

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Cell death
Reactive Oxygen Species
Cell Death
Ultrasonics
Chemical activation
Rose Bengal
Light
Methylene Blue
Lethal Dose 50
Pharmaceutical Preparations

Cite this

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abstract = "A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.",
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Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. / McCaughan, Bridgeen; Rouanet, C; Fowley, Colin; Nomikou, N; McHale, Anthony; Callan, John.

Vol. 21, No. 19, 01.10.2011, p. 5750-5752.

Research output: Contribution to journalArticle

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AU - Callan, John

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