A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.
McCaughan, B., Rouanet, C., Fowley, C., Nomikou, N., McHale, A., & Callan, J. (2011). Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. Bioorganic and Medicinal Chemistry Letters, 21(19), 5750-5752. https://doi.org/10.1016/j.bmcl.2011.08.015