Engineering Three-Dimensional Bendable Helix Conduits for Peripheral Nerve Regeneration via Hybrid Electrotechnologies

Renyuan Sun, Baolin Wang, Longfei Zhang, Yuna Lang, Ming-Wei Chang

Research output: Contribution to journalLetterpeer-review

Abstract

Nerve guidance conduits (NGCs) are considered as the best alternative approach to autologous nerve grafting for treating peripheral nerve injuries (PNI). The bendable NGCs are desirable in practical use but are still difficult to fabricate. In this study, the hybrid electrotechnologies combining electrohydrodynamic (EHD) printing and electrospinning were applied to produce a novel bendable helix conduit with tunable flexibility. Helical polycaprolactone (PCL) foundations were constructed via EHD printing for mechanical support, on which electrospinning PCL membrane was coated to form the bendable helix conduits and keep the entire structure stable. The effects of helical foundation with different helical height on the properties of NGCs were analyzed. In addition, these three-dimensional (3D) bendable helix conduits had excellent resistance to compression and fatigue. Moreover, the bendable conduits had higher specific surface area, which is beneficial to the adsorption of RSC96 cells. Therefore, the 3D bendable helix conduits show great potential in clinical application for treating PNI.
Original languageEnglish
Pages (from-to)2210-2218
Number of pages9
JournalACS Materials Letters
DOIs
Publication statusPublished online - 13 Oct 2022

Keywords

  • General Materials Science
  • Biomedical Engineering
  • General Chemical Engineering

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