Engineering On‐Demand Magnetic Core‐Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro Scale Printing

Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-wei Chang

Research output: Contribution to journalArticle

Abstract

Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core–shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core–shell fibers. In addition, adding iron oxide (Fe 3O 4) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

LanguageEnglish
Article number1900699
JournalAdvanced Engineering Materials
DOIs
Publication statusPublished - 23 Jul 2019

Fingerprint

Magnetic cores
magnetic cores
Electrohydrodynamics
electrohydrodynamics
hydrochlorides
tetracyclines
printing
Printing
Polycaprolactone
engineering
Polyethylene oxides
Tetracycline
composite materials
fibers
Fibers
Composite materials
matrices
drugs
Nanoparticles
Lidocaine

Keywords

  • coaxial
  • drug release
  • matrices
  • printing
  • wound dressings

Cite this

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abstract = "Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core–shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5{\%} w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core–shell fibers. In addition, adding iron oxide (Fe 3O 4) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.",
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Engineering On‐Demand Magnetic Core‐Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro Scale Printing. / Wang, Baolin; Chen, Xing; Ahmad, Zeeshan; Huang, Jie; Chang, Ming-wei.

23.07.2019.

Research output: Contribution to journalArticle

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T1 - Engineering On‐Demand Magnetic Core‐Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro Scale Printing

AU - Wang, Baolin

AU - Chen, Xing

AU - Ahmad, Zeeshan

AU - Huang, Jie

AU - Chang, Ming-wei

PY - 2019/7/23

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N2 - Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core–shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core–shell fibers. In addition, adding iron oxide (Fe 3O 4) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

AB - Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core–shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core–shell fibers. In addition, adding iron oxide (Fe 3O 4) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

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