Engineering On‐Demand Magnetic Core‐Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro Scale Printing

Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-wei Chang

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
93 Downloads (Pure)


Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core–shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core–shell fibers. In addition, adding iron oxide (Fe 3O 4) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

Original languageEnglish
Article number1900699
Pages (from-to)1-15
Number of pages15
JournalAdvanced Engineering Materials
Issue number10
Early online date23 Jul 2019
Publication statusPublished (in print/issue) - 1 Oct 2019

Bibliographical note

Funding Information:
This research was financially supported by Major Scientific Project of Zhejiang Lab (No. 2018DG0ZX01), the National Nature Science Foundation of China (No. 81771960), the Fundamental Research Funds for the Central Universities (2017QNA5017), and Key Technologies R&D Program of Zhejiang Province (2015C02035).

Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Copyright 2019 Elsevier B.V., All rights reserved.


  • coaxial
  • drug release
  • matrices
  • printing
  • wound dressings


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