Abstract
Nanofibers comprising dispersed natural bioactive ingredients have received considerable attention due to enhanced pharmaceutical effects. Ganoderma lucidum polysaccharide (GLP) is a versatile bioactive compound that is prone to oxidative damage. In this work, GLP was obtained from Ganoderma lucidum spore powder (GLSP) using two methods; ultrasound-assisted extraction (UAE) and traditional solvent extraction (TSE). Optimal GLP yield was determined via parametric optimization for UAE. GLP was subsequently loaded (via electrospinning) as a molecularly dispersed system into polyvinyl alcohol (PVA) nanofibers; which ranged in size from 390 to 750 nm. Composite fibers were analyzed using electron microscopy, Fourier Transform Infrared spectroscopy, and their surface hydrophilicity and mechanical properties were assessed. The results showed that the yield of GLP using UAE for 3 min was higher than that of TSE for 5 h. GLP concentration was shown to influence mean fiber diameter, water contact angle and maximum tensile/strain strength of fibrous composite films. All fibrous films exhibited rapid GLP release, reaching 100% within 300 s. These results demonstrate an efficient method for GLP preparation and a feasible route to encapsulate the compound as a molecularly dispersed system into nanofibers, elucidating potential application in biopharmaceutical delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 208-216 |
| Number of pages | 9 |
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 50 |
| Early online date | 23 Jan 2019 |
| DOIs | |
| Publication status | Published (in print/issue) - 1 Apr 2019 |
Keywords
- Blended nanofiber
- Electrospinning
- Ganoderma lucidum polysaccharide
- Ultrasound