Engineering of Ganoderma lucidum polysaccharide loaded polyvinyl alcohol nanofibers for biopharmaceutical delivery

Li Fang Zhu, Xianle Chen, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Nanofibers comprising dispersed natural bioactive ingredients have received considerable attention due to enhanced pharmaceutical effects. Ganoderma lucidum polysaccharide (GLP) is a versatile bioactive compound that is prone to oxidative damage. In this work, GLP was obtained from Ganoderma lucidum spore powder (GLSP) using two methods; ultrasound-assisted extraction (UAE) and traditional solvent extraction (TSE). Optimal GLP yield was determined via parametric optimization for UAE. GLP was subsequently loaded (via electrospinning) as a molecularly dispersed system into polyvinyl alcohol (PVA) nanofibers; which ranged in size from 390 to 750 nm. Composite fibers were analyzed using electron microscopy, Fourier Transform Infrared spectroscopy, and their surface hydrophilicity and mechanical properties were assessed. The results showed that the yield of GLP using UAE for 3 min was higher than that of TSE for 5 h. GLP concentration was shown to influence mean fiber diameter, water contact angle and maximum tensile/strain strength of fibrous composite films. All fibrous films exhibited rapid GLP release, reaching 100% within 300 s. These results demonstrate an efficient method for GLP preparation and a feasible route to encapsulate the compound as a molecularly dispersed system into nanofibers, elucidating potential application in biopharmaceutical delivery.

Original languageEnglish
Pages (from-to)208-216
Number of pages9
JournalJournal of Drug Delivery Science and Technology
Volume50
Early online date23 Jan 2019
DOIs
Publication statusPublished - 1 Apr 2019

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Keywords

  • Blended nanofiber
  • Electrospinning
  • Ganoderma lucidum polysaccharide
  • Ultrasound

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