Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses

Prina Mehta, Ali A. Al-Kinani, Muhammad Sohail Arshad, Neenu Singh, Susanna M. van der Merwe, Ming Wei Chang, Raid G. Alany, Zeeshan Ahmad

Research output: Contribution to journalArticle

Abstract

This article reports on electrohydrodynamic atomization to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone and poly (N-isopropylacrylamide) were utilized to encapsulate TM and were electrically atomized to produce optimized, stationary contact lens coatings. The particle and fiber diameter, thermal stability, material compatibility of the formed coatings, their in vitro release-modulating effect, and ocular tolerability were investigated. Results demonstrated highly stable nanomatrices with advantageous morphology and size. All formulations yielded coatings with high TM encapsulation (>88%) and excellent ocular biocompatibility. Coatings yielded biphasic and triphasic release, depending on composition. Kinetic modeling revealed a noticeable effect of chitosan; the higher the concentration, the more the release of TM because of chitosan swelling, with the mechanism changing from Fickian diffusion (1% w/v; n = 0.5) to non-Fickian (5% w/v, 0.45 < n < 0.89). The use of electrohydrodynamic atomization has not yet been explored in depth within the ocular research remit, engineering on-demand lens coatings capable of sustaining TM release. This is likely to offer an alternative dosage form for management of glaucoma with particular emphasis on improving poor patient compliance.

LanguageEnglish
Pages1540-1551
Number of pages12
JournalJournal of Pharmaceutical Sciences
Volume108
Issue number4
Early online date1 Dec 2018
DOIs
Publication statusPublished - 1 Apr 2019

Fingerprint

Timolol
Crystalline Lens
Contact Lenses
Chitosan
Povidone
Dosage Forms
Patient Compliance
Glaucoma
Lenses
Polymers
Hot Temperature
Research

Keywords

  • coating
  • contact lense(s)
  • controlled release
  • ophthalmic drug delivery
  • polymer(s)

Cite this

Mehta, P., Al-Kinani, A. A., Arshad, M. S., Singh, N., van der Merwe, S. M., Chang, M. W., ... Ahmad, Z. (2019). Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses. Journal of Pharmaceutical Sciences, 108(4), 1540-1551. https://doi.org/10.1016/j.xphs.2018.11.036
Mehta, Prina ; Al-Kinani, Ali A. ; Arshad, Muhammad Sohail ; Singh, Neenu ; van der Merwe, Susanna M. ; Chang, Ming Wei ; Alany, Raid G. ; Ahmad, Zeeshan. / Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses. In: Journal of Pharmaceutical Sciences. 2019 ; Vol. 108, No. 4. pp. 1540-1551.
@article{f8b6b94d381b4bc9babb10ee92e519e7,
title = "Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses",
abstract = "This article reports on electrohydrodynamic atomization to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone and poly (N-isopropylacrylamide) were utilized to encapsulate TM and were electrically atomized to produce optimized, stationary contact lens coatings. The particle and fiber diameter, thermal stability, material compatibility of the formed coatings, their in vitro release-modulating effect, and ocular tolerability were investigated. Results demonstrated highly stable nanomatrices with advantageous morphology and size. All formulations yielded coatings with high TM encapsulation (>88{\%}) and excellent ocular biocompatibility. Coatings yielded biphasic and triphasic release, depending on composition. Kinetic modeling revealed a noticeable effect of chitosan; the higher the concentration, the more the release of TM because of chitosan swelling, with the mechanism changing from Fickian diffusion (1{\%} w/v; n = 0.5) to non-Fickian (5{\%} w/v, 0.45 < n < 0.89). The use of electrohydrodynamic atomization has not yet been explored in depth within the ocular research remit, engineering on-demand lens coatings capable of sustaining TM release. This is likely to offer an alternative dosage form for management of glaucoma with particular emphasis on improving poor patient compliance.",
keywords = "coating, contact lense(s), controlled release, ophthalmic drug delivery, polymer(s)",
author = "Prina Mehta and Al-Kinani, {Ali A.} and Arshad, {Muhammad Sohail} and Neenu Singh and {van der Merwe}, {Susanna M.} and Chang, {Ming Wei} and Alany, {Raid G.} and Zeeshan Ahmad",
note = "Available on De Montfort repository. No accepted version uploaded, not for REF.",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.xphs.2018.11.036",
language = "English",
volume = "108",
pages = "1540--1551",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "4",

}

Mehta, P, Al-Kinani, AA, Arshad, MS, Singh, N, van der Merwe, SM, Chang, MW, Alany, RG & Ahmad, Z 2019, 'Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses', Journal of Pharmaceutical Sciences, vol. 108, no. 4, pp. 1540-1551. https://doi.org/10.1016/j.xphs.2018.11.036

Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses. / Mehta, Prina; Al-Kinani, Ali A.; Arshad, Muhammad Sohail; Singh, Neenu; van der Merwe, Susanna M.; Chang, Ming Wei; Alany, Raid G.; Ahmad, Zeeshan.

In: Journal of Pharmaceutical Sciences, Vol. 108, No. 4, 01.04.2019, p. 1540-1551.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses

AU - Mehta, Prina

AU - Al-Kinani, Ali A.

AU - Arshad, Muhammad Sohail

AU - Singh, Neenu

AU - van der Merwe, Susanna M.

AU - Chang, Ming Wei

AU - Alany, Raid G.

AU - Ahmad, Zeeshan

N1 - Available on De Montfort repository. No accepted version uploaded, not for REF.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - This article reports on electrohydrodynamic atomization to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone and poly (N-isopropylacrylamide) were utilized to encapsulate TM and were electrically atomized to produce optimized, stationary contact lens coatings. The particle and fiber diameter, thermal stability, material compatibility of the formed coatings, their in vitro release-modulating effect, and ocular tolerability were investigated. Results demonstrated highly stable nanomatrices with advantageous morphology and size. All formulations yielded coatings with high TM encapsulation (>88%) and excellent ocular biocompatibility. Coatings yielded biphasic and triphasic release, depending on composition. Kinetic modeling revealed a noticeable effect of chitosan; the higher the concentration, the more the release of TM because of chitosan swelling, with the mechanism changing from Fickian diffusion (1% w/v; n = 0.5) to non-Fickian (5% w/v, 0.45 < n < 0.89). The use of electrohydrodynamic atomization has not yet been explored in depth within the ocular research remit, engineering on-demand lens coatings capable of sustaining TM release. This is likely to offer an alternative dosage form for management of glaucoma with particular emphasis on improving poor patient compliance.

AB - This article reports on electrohydrodynamic atomization to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone and poly (N-isopropylacrylamide) were utilized to encapsulate TM and were electrically atomized to produce optimized, stationary contact lens coatings. The particle and fiber diameter, thermal stability, material compatibility of the formed coatings, their in vitro release-modulating effect, and ocular tolerability were investigated. Results demonstrated highly stable nanomatrices with advantageous morphology and size. All formulations yielded coatings with high TM encapsulation (>88%) and excellent ocular biocompatibility. Coatings yielded biphasic and triphasic release, depending on composition. Kinetic modeling revealed a noticeable effect of chitosan; the higher the concentration, the more the release of TM because of chitosan swelling, with the mechanism changing from Fickian diffusion (1% w/v; n = 0.5) to non-Fickian (5% w/v, 0.45 < n < 0.89). The use of electrohydrodynamic atomization has not yet been explored in depth within the ocular research remit, engineering on-demand lens coatings capable of sustaining TM release. This is likely to offer an alternative dosage form for management of glaucoma with particular emphasis on improving poor patient compliance.

KW - coating

KW - contact lense(s)

KW - controlled release

KW - ophthalmic drug delivery

KW - polymer(s)

UR - http://www.scopus.com/inward/record.url?scp=85060299449&partnerID=8YFLogxK

U2 - 10.1016/j.xphs.2018.11.036

DO - 10.1016/j.xphs.2018.11.036

M3 - Article

VL - 108

SP - 1540

EP - 1551

JO - Journal of Pharmaceutical Sciences

T2 - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 4

ER -