Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses

Prina Mehta, Ali A. Al-Kinani, Muhammad Sohail Arshad, Neenu Singh, Susanna M. van der Merwe, Ming Wei Chang, Raid G. Alany, Zeeshan Ahmad

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This article reports on electrohydrodynamic atomization to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone and poly (N-isopropylacrylamide) were utilized to encapsulate TM and were electrically atomized to produce optimized, stationary contact lens coatings. The particle and fiber diameter, thermal stability, material compatibility of the formed coatings, their in vitro release-modulating effect, and ocular tolerability were investigated. Results demonstrated highly stable nanomatrices with advantageous morphology and size. All formulations yielded coatings with high TM encapsulation (>88%) and excellent ocular biocompatibility. Coatings yielded biphasic and triphasic release, depending on composition. Kinetic modeling revealed a noticeable effect of chitosan; the higher the concentration, the more the release of TM because of chitosan swelling, with the mechanism changing from Fickian diffusion (1% w/v; n = 0.5) to non-Fickian (5% w/v, 0.45 < n < 0.89). The use of electrohydrodynamic atomization has not yet been explored in depth within the ocular research remit, engineering on-demand lens coatings capable of sustaining TM release. This is likely to offer an alternative dosage form for management of glaucoma with particular emphasis on improving poor patient compliance.

Original languageEnglish
Pages (from-to)1540-1551
Number of pages12
JournalJournal of Pharmaceutical Sciences
Volume108
Issue number4
Early online date1 Dec 2018
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • coating
  • contact lense(s)
  • controlled release
  • ophthalmic drug delivery
  • polymer(s)

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  • Cite this

    Mehta, P., Al-Kinani, A. A., Arshad, M. S., Singh, N., van der Merwe, S. M., Chang, M. W., Alany, R. G., & Ahmad, Z. (2019). Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses. Journal of Pharmaceutical Sciences, 108(4), 1540-1551. https://doi.org/10.1016/j.xphs.2018.11.036