Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals

Adeola A. Sanni‐Ajibaye, Anson M. Blanks, Cassandra C. Derella, Abigayle B. Simon, Paula Rodriguez‐Miguelez, Jacob Looney, Jinhee Jeong, Jeffrey Thomas, David W. Stepp, Neal L. Weintraub, Xiaoling Wang, Ryan A. Harris

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    Upregulation of endothelin-1 (ET-1) is the hallmark of various cardiovascular diseases (CVD). The purpose of the present study was to assess the ET-1 response to an acute bout of whole-body vibration (WBV) in humans and to determine the role of adiposity. Twenty-two participants volunteered for the study; they were grouped into overweight/obese [(OW/OB): n = 11, Age: 33 ± 4 years, Body mass index (BMI): 35 ± 10 kg/m2] or normal weight [(NW): n = 11, Age: 28 ± 7 years, BMI: 21 ± 2 kg/m2]. Participants engaged in 10 cycles of WBV exercise (1 cycle = 1 min WBV followed by 30 s of rest). Blood samples were analyzed for ET-1 pre-WBV (PRE), immediately post (POST), 1 h (1H), 3 h (3H), and 24 h (24H) post-WBV. There was a significant time main effect of WBV on circulating ET-1 (F = 12.5, p < 0.001); however, the ET-1 response was similar (F = 0.180, p = 0.677) between groups. Specifically, compared to PRE, a significant increase in ET-1 was observed at 1H (p = 0.017) and 3H (p = 0.025). In addition, concentrations of ET-1 were significantly lower at 24H compared to PRE (p = 0.019), 1H (p < 0.001), and 3H (p < 0.001). Maximal oxygen uptake during WBV was similar between the two groups. Acute WBV resulted in an initial rise in ET-1, followed by a significantly lower ET-1 at 24H in both groups. Findings support the utility of routine WBV exercise to elicit a decrease in ET-1 and improve CVD risk, similar to what has been reported with traditional modes of exercise.
    Original languageEnglish
    Article numbere15335
    Pages (from-to)1-8
    Number of pages8
    JournalPhysiological Reports
    Issue number10
    Early online date20 May 2022
    Publication statusPublished (in print/issue) - 20 May 2022

    Bibliographical note

    Funding Information:
    This project was supported, in part, by an Augusta University Collaborative Proposal Award (RAH and DWS) and NIH 1R01DK117365 (RAH and XW)

    Publisher Copyright:
    © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.


    • Physiology (medical)
    • Physiology
    • Young Adult
    • Cardiovascular Diseases
    • Vibration
    • Humans
    • Endothelin-1
    • Obesity/therapy
    • Adult
    • Exercise/physiology
    • adiposity
    • exercise
    • whole-body vibration
    • endothelin-1


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