Abstract
The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its ubiquitous guanines. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications.
Original language | English |
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Article number | eaat3007 |
Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Science Advances |
Volume | 4 |
Issue number | aat3007 |
DOIs | |
Publication status | Published (in print/issue) - 31 Aug 2018 |
Keywords
- quadruplex
- dna structure
- programming dna
- coding dna
- G-quadruplex
- NMR structure
- canonical dna quadruplex
- quadruplex structure