Encoding canonical DNA quadruplex structure

Scarlett Dvorkin, Andreas I. Karsisiotis, Mateus Webba da Silva

Research output: Contribution to journalArticle

15 Citations (Scopus)
8 Downloads (Pure)

Abstract

The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its ubiquitous guanines. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications.
Original languageEnglish
Article numbereaat3007
Pages (from-to)1-10
Number of pages10
JournalScience Advances
Volume4
Issue numberaat3007
DOIs
Publication statusPublished - 31 Aug 2018

Keywords

  • quadruplex
  • dna structure
  • programming dna
  • coding dna
  • G-quadruplex
  • NMR structure
  • canonical dna quadruplex
  • quadruplex structure

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