Encoding canonical DNA quadruplex structure

Scarlett Dvorkin, Andreas I. Karsisiotis, Mateus Webba da Silva

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)
139 Downloads (Pure)


The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its ubiquitous guanines. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications.
Original languageEnglish
Article numbereaat3007
Pages (from-to)1-10
Number of pages10
JournalScience Advances
Issue numberaat3007
Publication statusPublished (in print/issue) - 31 Aug 2018


  • quadruplex
  • dna structure
  • programming dna
  • coding dna
  • G-quadruplex
  • NMR structure
  • canonical dna quadruplex
  • quadruplex structure


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