Encoding canonical DNA quadruplex structure

Scarlett Dvorkin; Andreas I. Karsisiotis; Mateus Webba da Silva

doi:10.1126/sciadv.aat3007

Encoding canonical DNA quadruplex structure

Scarlett Dvorkin, Andreas I. Karsisiotis, Mateus Webba da Silva

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

160 Downloads (Pure)

Abstract

The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its ubiquitous guanines. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications.

Original language	English
Article number	eaat3007
Pages (from-to)	1-10
Number of pages	10
Journal	Science Advances
Volume	4
Issue number	aat3007
DOIs	https://doi.org/10.1126/sciadv.aat3007
Publication status	Published (in print/issue) - 31 Aug 2018

Keywords

quadruplex
dna structure
programming dna
coding dna
G-quadruplex
NMR structure
canonical dna quadruplex
quadruplex structure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/sciadv.aat3007Licence: CC BY

aat3007_AllAuthor Accepted Manuscript, 26.3 MBLicence: CC BY

Cite this

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KW - programming dna

KW - coding dna

KW - G-quadruplex

KW - NMR structure

KW - canonical dna quadruplex

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Encoding canonical DNA quadruplex structure

Abstract

Keywords

UN SDGs

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Mateus Webba Da Silva

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Encoding canonical DNA quadruplex structure

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Profiles

Mateus Webba Da Silva

Cite this