Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Vijay Mishra, Pallavi Nayak, Mayank Sharma, Aqel Albutti, Ameen S. S. Alwashmi, Mohammad Abdullah Aljasir, Noorah Alsowayeh, Murtaza M. Tambuwala

Research output: Contribution to journalArticlepeer-review

Abstract

The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediated
functional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnology
in diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as -cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs,
are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.
Original languageEnglish
Article number1568
Number of pages33
JournalPharmaceutics
Volume13
Issue number10
DOIs
Publication statusPublished - 27 Sep 2021

Keywords

  • diabetes mellitus
  • nanocarrier

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