Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Vijay Mishra; Pallavi Nayak; Mayank Sharma; Aqel Albutti; Ameen S. S. Alwashmi; Mohammad Abdullah Aljasir; Noorah Alsowayeh; Murtaza M. Tambuwala

doi:10.3390/pharmaceutics13101568

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Vijay Mishra, Pallavi Nayak, Mayank Sharma, Aqel Albutti, Ameen S. S. Alwashmi, Mohammad Abdullah Aljasir, Noorah Alsowayeh, Murtaza M. Tambuwala

Faculty Of Life & Health Sciences

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

99 Downloads (Pure)

Abstract

The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediated
functional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnology
in diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as -cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs,
are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.

Original language	English
Article number	1568
Number of pages	33
Journal	Pharmaceutics
Volume	13
Issue number	10
DOIs	https://doi.org/10.3390/pharmaceutics13101568
Publication status	Published (in print/issue) - 27 Sept 2021

Bibliographical note

Funding Information:
Funding: The researchers would like to thank the Deanship of Scientific Research, Qassim University for funding the publication of this project.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

diabetes mellitus
nanocarrier
Nanocarrier
Blood glucose level
Diabetes mellitus
Treatment strategies
Insulin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/pharmaceutics13101568Licence: CC BY

pharmaceutics-13-01568-v2Final published version, 5.35 MBLicence: CC BY

https://www.mdpi.com/1999-4923/13/10/1568

Cite this

@article{aa7c46ff0c5e4502a49973e4a0fec465,

title = "Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update",

abstract = "The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediatedfunctional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnologyin diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as -cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs,are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.",

keywords = "diabetes mellitus, nanocarrier, Nanocarrier, Blood glucose level, Diabetes mellitus, Treatment strategies, Insulin",

author = "Vijay Mishra and Pallavi Nayak and Mayank Sharma and Aqel Albutti and Alwashmi, {Ameen S. S.} and Aljasir, {Mohammad Abdullah} and Noorah Alsowayeh and Tambuwala, {Murtaza M.}",

note = "Funding Information: Funding: The researchers would like to thank the Deanship of Scientific Research, Qassim University for funding the publication of this project. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

day = "27",

doi = "10.3390/pharmaceutics13101568",

language = "English",

volume = "13",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI",

number = "10",

}

TY - JOUR

T1 - Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

AU - Mishra, Vijay

AU - Nayak, Pallavi

AU - Sharma, Mayank

AU - Albutti, Aqel

AU - Alwashmi, Ameen S. S.

AU - Aljasir, Mohammad Abdullah

AU - Alsowayeh, Noorah

AU - Tambuwala, Murtaza M.

N1 - Funding Information: Funding: The researchers would like to thank the Deanship of Scientific Research, Qassim University for funding the publication of this project. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/9/27

Y1 - 2021/9/27

N2 - The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediatedfunctional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnologyin diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as -cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs,are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.

AB - The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediatedfunctional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnologyin diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as -cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs,are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.

KW - diabetes mellitus

KW - nanocarrier

KW - Nanocarrier

KW - Blood glucose level

KW - Diabetes mellitus

KW - Treatment strategies

KW - Insulin

UR - http://www.scopus.com/inward/record.url?scp=85116314070&partnerID=8YFLogxK

U2 - 10.3390/pharmaceutics13101568

DO - 10.3390/pharmaceutics13101568

M3 - Review article

C2 - 34683861

SN - 1999-4923

VL - 13

JO - Pharmaceutics

JF - Pharmaceutics

IS - 10

M1 - 1568

ER -

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this