TY - JOUR
T1 - Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms
AU - Chan, Yinghan
AU - Ng, Sin Wi
AU - Xin Tan, Joycelin Zhu
AU - Gupta, Gaurav
AU - Tambuwala, Murtaza M.
AU - Bakshi, Hamid A.
AU - Dureja, Harish
AU - Dua, Kamal
AU - Ishaq, Muhammad
AU - Caruso, Vanni
AU - Chellappan, Dinesh Kumar
PY - 2020/1/5
Y1 - 2020/1/5
N2 - Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.
AB - Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.
KW - Anti-Cancer
KW - Anti-Obesity
KW - Anti-bacterial
KW - Anti-inflammatory
KW - Asperuloside
KW - Laxative
UR - http://www.scopus.com/inward/record.url?scp=85075777802&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/31786185/
UR - https://linkinghub.elsevier.com/retrieve/pii/S0009279719316643
U2 - 10.1016/j.cbi.2019.108911
DO - 10.1016/j.cbi.2019.108911
M3 - Article
C2 - 31786185
SN - 0009-2797
VL - 315
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
M1 - 108911
ER -
