Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms

Yinghan Chan, Sin Wi Ng, Joycelin Zhu Xin Tan, Gaurav Gupta, Murtaza M. Tambuwala, Hamid A. Bakshi, Harish Dureja, Kamal Dua, Muhammad Ishaq, Vanni Caruso, Dinesh Kumar Chellappan

Research output: Contribution to journalArticle

Abstract

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.
LanguageEnglish
Article number108911
Number of pages43
JournalChemico-Biological Interactions
Volume315
Early online date28 Nov 2019
DOIs
Publication statusPublished - 5 Jan 2020

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Molecules
Iridoid Glycosides
Pharmacology
Plant Extracts
Drug Discovery
Biological Products
Toxicology
Medicine
Therapeutics
Research Personnel
Research
asperuloside

Keywords

  • Anti-Cancer
  • Anti-Obesity
  • Anti-bacterial
  • Anti-inflammatory
  • Asperuloside
  • Laxative

Cite this

Chan, Yinghan ; Ng, Sin Wi ; Xin Tan, Joycelin Zhu ; Gupta, Gaurav ; Tambuwala, Murtaza M. ; Bakshi, Hamid A. ; Dureja, Harish ; Dua, Kamal ; Ishaq, Muhammad ; Caruso, Vanni ; Chellappan, Dinesh Kumar. / Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms. In: Chemico-Biological Interactions. 2020 ; Vol. 315.
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Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms. / Chan, Yinghan; Ng, Sin Wi; Xin Tan, Joycelin Zhu; Gupta, Gaurav; Tambuwala, Murtaza M.; Bakshi, Hamid A.; Dureja, Harish; Dua, Kamal; Ishaq, Muhammad; Caruso, Vanni; Chellappan, Dinesh Kumar.

In: Chemico-Biological Interactions, Vol. 315, 108911, 05.01.2020.

Research output: Contribution to journalArticle

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