Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Abhishek Kumar Sharma; Parteek Prasher; Alaa A. Aljabali; Vijay Mishra; Himanshu Gandhi; Sunil Kumar; Srinivas Mutalik; Dinesh Kumar Chellappan; Murtaza M. Tambuwala; Kamal Dua; Deepak N. Kapoor

doi:10.1007/s13346-020-00789-2

Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Abhishek Kumar Sharma, Parteek Prasher, Alaa A. Aljabali, Vijay Mishra, Himanshu Gandhi, Sunil Kumar, Srinivas Mutalik, Dinesh Kumar Chellappan, Murtaza M. Tambuwala, Kamal Dua, Deepak N. Kapoor

Research output: Contribution to journal › Review article › peer-review

65 Citations (Scopus)

35 Downloads (Pure)

Abstract

Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis.

Original language	English
Pages (from-to)	1171-1190
Number of pages	20
Journal	Drug Delivery and Translational Research
Volume	10
Issue number	5
Early online date	5 Jun 2020
DOIs	https://doi.org/10.1007/s13346-020-00789-2
Publication status	Published (in print/issue) - 1 Oct 2020

Keywords

cancer therapy
drug delivery
nanomedicine
nanotechnology
polymersomes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13346-020-00789-2

Polymersomes Final SubmittedAuthor Accepted Manuscript, 2.29 MB

http://link.springer.com/10.1007/s13346-020-00789-2

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Sharma, A. K., Prasher, P., Aljabali, A. A., Mishra, V., Gandhi, H., Kumar, S., Mutalik, S., Chellappan, D. K., Tambuwala, M. M., Dua, K., & Kapoor, D. N. (2020). Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy. Drug Delivery and Translational Research, 10(5), 1171-1190. https://doi.org/10.1007/s13346-020-00789-2

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abstract = "Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis.",

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AU - Sharma, Abhishek Kumar

AU - Prasher, Parteek

AU - Aljabali, Alaa A.

AU - Mishra, Vijay

AU - Gandhi, Himanshu

AU - Kumar, Sunil

AU - Mutalik, Srinivas

AU - Chellappan, Dinesh Kumar

AU - Tambuwala, Murtaza M.

AU - Dua, Kamal

AU - Kapoor, Deepak N.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis.

AB - Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis.

KW - cancer therapy

KW - drug delivery

KW - nanomedicine

KW - nanotechnology

KW - polymersomes

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U2 - 10.1007/s13346-020-00789-2

DO - 10.1007/s13346-020-00789-2

M3 - Review article

C2 - 32504410

SN - 2190-393X

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JO - Drug Delivery and Translational Research

JF - Drug Delivery and Translational Research

IS - 5

ER -

Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Abstract

Keywords

UN SDGs

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