Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function

Sk. Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-aroca, Parise Adadi, Alaa A.a. Aljabali, Elrashdy M. Redwan, Amos Lal, Ramesh Kandimalla, Tarek Mohamed Abd El-aziz, Pabitra Pal Choudhury, Gajendra Kumar Azad, Samendra P. Sherchan, Gaurav Chauhan, Murtaza Tambuwala, Kazuo Takayama, Debmalya Barh, Giorgio Palu, Pallab Basu, Vladimir N. Uversky

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
48 Downloads (Pure)

Abstract

The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made targeting the COVID-19 pandemic a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in lung tissue. Mutations and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, we highlight 128 single mutations and 35 co-occurring mutations in the unique SARS-CoV-2 ORF10 variants. The possible predicted effects of these mutations and co-occurring mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-occurring mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
Original languageEnglish
Pages (from-to)128-143
Number of pages16
JournalInternational Journal of Biological Macromolecules
Volume194
Early online date2 Dec 2021
DOIs
Publication statusPublished (in print/issue) - 1 Jan 2022

Bibliographical note

Funding Information:
We gratefully acknowledge the authors from the originating laboratories responsible for obtaining the specimens and the Submitting laboratories where genetic sequence data were generated and shared via the NCBI and GISAID Initiatives, on which this research is based.

Publisher Copyright:
© 2021

Keywords

  • And Ubiquitin Ligase Complex
  • COVID-19
  • Co-occurring Mutations
  • Host Microbial Interactions
  • Humans
  • Intrinsic Protein Disorder
  • Mutation
  • Open Reading Frames
  • Orf10
  • SARS-CoV-2
  • Viral Proteins
  • And ubiquitin ligase complex
  • SARS-CoV-2/genetics
  • Viral Proteins/genetics
  • COVID-19/virology

Fingerprint

Dive into the research topics of 'Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function'. Together they form a unique fingerprint.

Cite this