Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

Nikhil Bhalla; Wen Yaw Danny Chung; Kerwin Wang; Teddy Lessmana; Pedro Estrela

doi:10.1109/ICSENS.2013.6688201

Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

Nikhil Bhalla, Wen Yaw Danny Chung, Kerwin Wang, Teddy Lessmana, Pedro Estrela

School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm 2 , which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

Original language	English
Pages	1-4
DOIs	https://doi.org/10.1109/ICSENS.2013.6688201
Publication status	Published (in print/issue) - 2013
Event	2013 IEEE Sensors - Baltimore, MD Duration: 3 Nov 2013 → 6 Nov 2013

Conference

Conference	2013 IEEE Sensors
Period	3/11/13 → 6/11/13

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10.1109/ICSENS.2013.6688201

http://ieeexplore.ieee.org/document/6688201/

Cite this

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title = "Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing",

abstract = "This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm 2 , which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.",

author = "Nikhil Bhalla and {Danny Chung}, {Wen Yaw} and Kerwin Wang and Teddy Lessmana and Pedro Estrela",

year = "2013",

doi = "10.1109/ICSENS.2013.6688201",

language = "English",

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T1 - Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

AU - Bhalla, Nikhil

AU - Danny Chung, Wen Yaw

AU - Wang, Kerwin

AU - Lessmana, Teddy

AU - Estrela, Pedro

PY - 2013

Y1 - 2013

N2 - This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm 2 , which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

AB - This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm 2 , which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

U2 - 10.1109/ICSENS.2013.6688201

DO - 10.1109/ICSENS.2013.6688201

M3 - Paper

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T2 - 2013 IEEE Sensors

Y2 - 3 November 2013 through 6 November 2013

ER -

Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

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