Electrospray ionisation-mass spectrometric characterisation of selected anti-psychotic drugs and their detection and determination in human hair samples by liquid chromatography-tandem mass spectrometry

Stephen McClean, EJ O'Kane, Franklin Smyth

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Electrospray ionisation quadrupole ion-trap mass spectrometric (ESI-MS) characterisation of the anti-psychotic drugs chlorpromazine, trifluoperazine, flupenthixol, risperidone and the antidepressant/internal standard trimipramine is presented and possible mechanisms for the observed MSn fragmentation patterns proposed. A validated liquid chromatography (LC)-MS-MS method is then applied to the detection and determination of these drugs in the hair of a patient under clinical treatment for schizophrenia. Chlorpromazine, trifluoperazine and flupenthixol are identified and determined in this hair sample following alkaline degradation of the matrix, solvent extraction and LC-MS-MS using trimipramine as internal standard. (C) 2000 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)141-157
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume740
Issue number2
Publication statusPublished - Apr 2000

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