Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites

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    Abstract

    A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.
    LanguageEnglish
    Pages1-16
    JournalAnalytica Chimica Acta
    Volume492
    Issue number1-2
    Publication statusPublished - Sep 2003

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    Electrospray ionization
    Metabolites
    Pharmaceutical Preparations
    Ions
    Mass spectrometry
    Molecules

    Cite this

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    title = "Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites",
    abstract = "A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.",
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    Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. / Smyth, Franklin.

    In: Analytica Chimica Acta, Vol. 492, No. 1-2, 09.2003, p. 1-16.

    Research output: Contribution to journalArticle

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    AB - A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.

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