Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites

Franklin Smyth

    Research output: Contribution to journal › Article

    41 Citations (Scopus)

    Abstract

    A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.
    LanguageEnglish
    Pages1-16
    JournalAnalytica Chimica Acta
    Volume492
    Issue number1-2
    Publication statusPublished - Sep 2003

    Fingerprint

    Electrospray ionization
    Metabolites
    Pharmaceutical Preparations
    Ions
    Mass spectrometry
    Molecules

    Cite this

    Smyth, Franklin. / Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. In: Analytica Chimica Acta. 2003 ; Vol. 492, No. 1-2. pp. 1-16.
    @article{cbf59c2d27ed4a8db6f7e2787b40a526,
    title = "Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites",
    abstract = "A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.",
    author = "Franklin Smyth",
    year = "2003",
    month = "9",
    language = "English",
    volume = "492",
    pages = "1--16",
    journal = "Analytica Chimica Acta",
    issn = "0003-2670",
    publisher = "Elsevier",
    number = "1-2",

    }

    Smyth, F 2003, 'Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites', Analytica Chimica Acta, vol. 492, no. 1-2, pp. 1-16.

    Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. / Smyth, Franklin.

    In: Analytica Chimica Acta, Vol. 492, No. 1-2, 09.2003, p. 1-16.

    Research output: Contribution to journal › Article

    TY - JOUR

    T1 - Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites

    AU - Smyth, Franklin

    PY - 2003/9

    Y1 - 2003/9

    N2 - A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.

    AB - A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.

    M3 - Article

    VL - 492

    SP - 1

    EP - 16

    JO - Analytica Chimica Acta

    T2 - Analytica Chimica Acta

    JF - Analytica Chimica Acta

    SN - 0003-2670

    IS - 1-2

    ER -

    Smyth F. Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. Analytica Chimica Acta. 2003 Sep;492(1-2):1-16.