Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours

Nikolitsa Nomikou, Anthony McHale

Research output: Contribution to journalArticle

3 Citations (Scopus)


Compromised turnout vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable turnout tissues. Here we demonstrate enhanced antitumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)202-208
JournalCancer Letters
Issue number2
Publication statusPublished - Jul 2009


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