Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours

Nikolitsa Nomikou, Anthony McHale

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Compromised turnout vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable turnout tissues. Here we demonstrate enhanced antitumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
LanguageEnglish
Pages202-208
JournalCancer Letters
Volume279
Issue number2
DOIs
Publication statusPublished - Jul 2009

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Pharmaceutical Preparations
Camptothecin
Neoplasms
Lung Neoplasms
Therapeutics

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abstract = "Compromised turnout vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable turnout tissues. Here we demonstrate enhanced antitumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.",
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Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours. / Nomikou, Nikolitsa; McHale, Anthony.

In: Cancer Letters, Vol. 279, No. 2, 07.2009, p. 202-208.

Research output: Contribution to journalArticle

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AU - McHale, Anthony

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AB - Compromised turnout vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable turnout tissues. Here we demonstrate enhanced antitumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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T2 - Cancer Letters

JF - Cancer Letters

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