Electrodeless dielectrophoretic concentrator for analyte pre-concentration on poly-silicon nanowire field effect transistor

Srinivasu Valagerahally Puttaswamy, Chih-heng Lin, Shilpa Sivashankar, Yuh-shyong Yang, Cheng-hsien Liu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The sensitivity of biosensors can be affected by mass transport limitations as a result of miniaturization. To enhance signal sensitivity, pre-concentration of deoxyribonucleic acid (DNA), in the vicinity of the sensing elements of n-type polycrystalline silicon nanowire field effect transistor (Poly-Si NWFET) is demonstrated using a microfluidic device based on insulator or gradient dielectrophoresis (iDEP) to overcome mass transport limitations. In insulator-based dielectrophoresis (iDEP), insulating microstructures produce non-uniform electric fields to drive dielectrophoresis (DEP) in microsystems. Fabrication of accurately controlled three-dimensional (3D) microstructure of poly (ethylene glycol) diacrylate (PEG-DA) with a narrow microchannel using maskless gray-scale lithography is described. The fabrication of three-dimensional structures at low cost with saving time is accomplished by the use of maskless exposure system. PEG-DA has been used due to its excellent biocompatibility and ease of fabrication. To enhance the stability of PEG-DA, we added another polymer pentaerythritol tetraacrylate (PETA). Electrical property of the Poly-Si NWFET is ensured by plotting I–VG curve after the integration of iDEP micro device.
LanguageEnglish
Pages547-554
JournalSensors and Actuators B: Chemical
Volume178
DOIs
Publication statusPublished - 1 Mar 2013

Fingerprint

concentrators
Silicon
Field effect transistors
Electrophoresis
Nanowires
nanowires
field effect transistors
Polyethylene glycols
glycols
microstructure
Microstructure
ethylene
insulators
silicon
Polysilicon
Fabrication
fabrication
Mass transfer
gradients
microfluidic devices

Keywords

  • FET biosensors
  • iDEP

Cite this

Puttaswamy, Srinivasu Valagerahally ; Lin, Chih-heng ; Sivashankar, Shilpa ; Yang, Yuh-shyong ; Liu, Cheng-hsien. / Electrodeless dielectrophoretic concentrator for analyte pre-concentration on poly-silicon nanowire field effect transistor. 2013 ; Vol. 178. pp. 547-554.
@article{8ebc5f71842c4021b7a7f51dd6400a31,
title = "Electrodeless dielectrophoretic concentrator for analyte pre-concentration on poly-silicon nanowire field effect transistor",
abstract = "The sensitivity of biosensors can be affected by mass transport limitations as a result of miniaturization. To enhance signal sensitivity, pre-concentration of deoxyribonucleic acid (DNA), in the vicinity of the sensing elements of n-type polycrystalline silicon nanowire field effect transistor (Poly-Si NWFET) is demonstrated using a microfluidic device based on insulator or gradient dielectrophoresis (iDEP) to overcome mass transport limitations. In insulator-based dielectrophoresis (iDEP), insulating microstructures produce non-uniform electric fields to drive dielectrophoresis (DEP) in microsystems. Fabrication of accurately controlled three-dimensional (3D) microstructure of poly (ethylene glycol) diacrylate (PEG-DA) with a narrow microchannel using maskless gray-scale lithography is described. The fabrication of three-dimensional structures at low cost with saving time is accomplished by the use of maskless exposure system. PEG-DA has been used due to its excellent biocompatibility and ease of fabrication. To enhance the stability of PEG-DA, we added another polymer pentaerythritol tetraacrylate (PETA). Electrical property of the Poly-Si NWFET is ensured by plotting I–VG curve after the integration of iDEP micro device.",
keywords = "FET biosensors, iDEP",
author = "Puttaswamy, {Srinivasu Valagerahally} and Chih-heng Lin and Shilpa Sivashankar and Yuh-shyong Yang and Cheng-hsien Liu",
year = "2013",
month = "3",
day = "1",
doi = "10.1016/j.snb.2013.01.016",
language = "English",
volume = "178",
pages = "547--554",

}

Electrodeless dielectrophoretic concentrator for analyte pre-concentration on poly-silicon nanowire field effect transistor. / Puttaswamy, Srinivasu Valagerahally; Lin, Chih-heng; Sivashankar, Shilpa; Yang, Yuh-shyong; Liu, Cheng-hsien.

Vol. 178, 01.03.2013, p. 547-554.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electrodeless dielectrophoretic concentrator for analyte pre-concentration on poly-silicon nanowire field effect transistor

AU - Puttaswamy, Srinivasu Valagerahally

AU - Lin, Chih-heng

AU - Sivashankar, Shilpa

AU - Yang, Yuh-shyong

AU - Liu, Cheng-hsien

PY - 2013/3/1

Y1 - 2013/3/1

N2 - The sensitivity of biosensors can be affected by mass transport limitations as a result of miniaturization. To enhance signal sensitivity, pre-concentration of deoxyribonucleic acid (DNA), in the vicinity of the sensing elements of n-type polycrystalline silicon nanowire field effect transistor (Poly-Si NWFET) is demonstrated using a microfluidic device based on insulator or gradient dielectrophoresis (iDEP) to overcome mass transport limitations. In insulator-based dielectrophoresis (iDEP), insulating microstructures produce non-uniform electric fields to drive dielectrophoresis (DEP) in microsystems. Fabrication of accurately controlled three-dimensional (3D) microstructure of poly (ethylene glycol) diacrylate (PEG-DA) with a narrow microchannel using maskless gray-scale lithography is described. The fabrication of three-dimensional structures at low cost with saving time is accomplished by the use of maskless exposure system. PEG-DA has been used due to its excellent biocompatibility and ease of fabrication. To enhance the stability of PEG-DA, we added another polymer pentaerythritol tetraacrylate (PETA). Electrical property of the Poly-Si NWFET is ensured by plotting I–VG curve after the integration of iDEP micro device.

AB - The sensitivity of biosensors can be affected by mass transport limitations as a result of miniaturization. To enhance signal sensitivity, pre-concentration of deoxyribonucleic acid (DNA), in the vicinity of the sensing elements of n-type polycrystalline silicon nanowire field effect transistor (Poly-Si NWFET) is demonstrated using a microfluidic device based on insulator or gradient dielectrophoresis (iDEP) to overcome mass transport limitations. In insulator-based dielectrophoresis (iDEP), insulating microstructures produce non-uniform electric fields to drive dielectrophoresis (DEP) in microsystems. Fabrication of accurately controlled three-dimensional (3D) microstructure of poly (ethylene glycol) diacrylate (PEG-DA) with a narrow microchannel using maskless gray-scale lithography is described. The fabrication of three-dimensional structures at low cost with saving time is accomplished by the use of maskless exposure system. PEG-DA has been used due to its excellent biocompatibility and ease of fabrication. To enhance the stability of PEG-DA, we added another polymer pentaerythritol tetraacrylate (PETA). Electrical property of the Poly-Si NWFET is ensured by plotting I–VG curve after the integration of iDEP micro device.

KW - FET biosensors

KW - iDEP

U2 - 10.1016/j.snb.2013.01.016

DO - 10.1016/j.snb.2013.01.016

M3 - Article

VL - 178

SP - 547

EP - 554

ER -