Electrochemically driven reagent release from an electronic suture

Fionnuala Morelli, Ashleigh Anderson, Anna McLister, John-Joe Fearon, James Davis

Research output: Contribution to journalArticle

Abstract

Sutures loaded with growth factors or antimicrobials are common place but the release of the therapeutic agent is almost invariably achieved through passive release mechanisms. A gold microwire loaded with cellulose acetate phthalate encapsulated drug droplets is proposed as an alternative design approach. The release mechanism relies upon the imposition of a suitable reducing potential at the gold suture resulting in an increase in local pH and thereby induces the dissolution of the polymeric binder and releases the drug. The ability to actively control the dissolution-release processes could lay the foundations for smart suture design where more responsive/metered dosing can be achieved.
LanguageEnglish
Pages70-73
JournalElectrochemistry Communications
Volume81
DOIs
Publication statusPublished - 1 Aug 2017

Fingerprint

Gold
Dissolution
Pharmaceutical Preparations
Binders
Intercellular Signaling Peptides and Proteins
cellulose acetate phthalate

Keywords

  • Smart suture
  • Wound diagnostics
  • Electronic textile
  • Drug delivery

Cite this

Morelli, Fionnuala ; Anderson, Ashleigh ; McLister, Anna ; Fearon, John-Joe ; Davis, James. / Electrochemically driven reagent release from an electronic suture. In: Electrochemistry Communications. 2017 ; Vol. 81. pp. 70-73.
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Electrochemically driven reagent release from an electronic suture. / Morelli, Fionnuala; Anderson, Ashleigh; McLister, Anna; Fearon, John-Joe; Davis, James.

In: Electrochemistry Communications, Vol. 81, 01.08.2017, p. 70-73.

Research output: Contribution to journalArticle

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AU - Anderson, Ashleigh

AU - McLister, Anna

AU - Fearon, John-Joe

AU - Davis, James

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KW - Wound diagnostics

KW - Electronic textile

KW - Drug delivery

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