Electrochemically Controlled Dissolution of Nanocarbon–Cellulose Acetate Phthalate Microneedle Arrays

J Davis, Ashleigh Anderson, Catherine Hegarty

Research output: Contribution to journalArticle

Abstract

Transdermal microneedles have captured the attention of researchers in relation to a variety of applications, and silicone-based molds required to produce these systems are now widely available and can be readily manufactured on the lab bench. The production of nanocomposite microneedle arrays through micromolding techniques is described. The formulation of nanoparticulate carbon along with pH sensitive cellulose acetate phthalate as a polymeric binder is shown to produce conductive microneedles whose swelling/dissolution properties can be controlled electrochemically. Through exploiting hydrogen evolution at the microneedle array, changes in local pH can induce swelling within the needle structure and could lay the foundations for a new approach to the smart device controlled delivery of therapeutic agents. The surface modification of the carbon needles with palladium and cysteine is critically assessed from sensing and drug delivery perspectives.
LanguageEnglish
Pages35540-35547
Number of pages8
JournalACS Applied Materials and Interfaces
Volume11
Issue number39
Early online date6 Sep 2019
DOIs
Publication statusPublished - 2 Oct 2019

Fingerprint

Needles
Swelling
Cellulose
Dissolution
Carbon
Palladium
Molds
Silicones
Drug delivery
Binders
Cysteine
Surface treatment
Hydrogen
Nanocomposites
cellulose acetate phthalate

Keywords

  • microneedle
  • transdermal
  • palladium
  • smart patch
  • drug delivery
  • HER
  • smart patches

Cite this

@article{0106f1a67b354382bda8b829242aefc5,
title = "Electrochemically Controlled Dissolution of Nanocarbon–Cellulose Acetate Phthalate Microneedle Arrays",
abstract = "Transdermal microneedles have captured the attention of researchers in relation to a variety of applications, and silicone-based molds required to produce these systems are now widely available and can be readily manufactured on the lab bench. The production of nanocomposite microneedle arrays through micromolding techniques is described. The formulation of nanoparticulate carbon along with pH sensitive cellulose acetate phthalate as a polymeric binder is shown to produce conductive microneedles whose swelling/dissolution properties can be controlled electrochemically. Through exploiting hydrogen evolution at the microneedle array, changes in local pH can induce swelling within the needle structure and could lay the foundations for a new approach to the smart device controlled delivery of therapeutic agents. The surface modification of the carbon needles with palladium and cysteine is critically assessed from sensing and drug delivery perspectives.",
keywords = "microneedle, transdermal, palladium, smart patch, drug delivery, HER, smart patches",
author = "J Davis and Ashleigh Anderson and Catherine Hegarty",
year = "2019",
month = "10",
day = "2",
doi = "10.1021/acsami.9b09674",
language = "English",
volume = "11",
pages = "35540--35547",
journal = "ACS Applied Materials and Interfaces",
issn = "1944-8244",
number = "39",

}

Electrochemically Controlled Dissolution of Nanocarbon–Cellulose Acetate Phthalate Microneedle Arrays. / Davis, J; Anderson, Ashleigh; Hegarty, Catherine.

In: ACS Applied Materials and Interfaces, Vol. 11, No. 39, 02.10.2019, p. 35540-35547.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electrochemically Controlled Dissolution of Nanocarbon–Cellulose Acetate Phthalate Microneedle Arrays

AU - Davis, J

AU - Anderson, Ashleigh

AU - Hegarty, Catherine

PY - 2019/10/2

Y1 - 2019/10/2

N2 - Transdermal microneedles have captured the attention of researchers in relation to a variety of applications, and silicone-based molds required to produce these systems are now widely available and can be readily manufactured on the lab bench. The production of nanocomposite microneedle arrays through micromolding techniques is described. The formulation of nanoparticulate carbon along with pH sensitive cellulose acetate phthalate as a polymeric binder is shown to produce conductive microneedles whose swelling/dissolution properties can be controlled electrochemically. Through exploiting hydrogen evolution at the microneedle array, changes in local pH can induce swelling within the needle structure and could lay the foundations for a new approach to the smart device controlled delivery of therapeutic agents. The surface modification of the carbon needles with palladium and cysteine is critically assessed from sensing and drug delivery perspectives.

AB - Transdermal microneedles have captured the attention of researchers in relation to a variety of applications, and silicone-based molds required to produce these systems are now widely available and can be readily manufactured on the lab bench. The production of nanocomposite microneedle arrays through micromolding techniques is described. The formulation of nanoparticulate carbon along with pH sensitive cellulose acetate phthalate as a polymeric binder is shown to produce conductive microneedles whose swelling/dissolution properties can be controlled electrochemically. Through exploiting hydrogen evolution at the microneedle array, changes in local pH can induce swelling within the needle structure and could lay the foundations for a new approach to the smart device controlled delivery of therapeutic agents. The surface modification of the carbon needles with palladium and cysteine is critically assessed from sensing and drug delivery perspectives.

KW - microneedle

KW - transdermal

KW - palladium

KW - smart patch

KW - drug delivery

KW - HER

KW - smart patches

UR - https://pubs.acs.org/doi/10.1021/acsami.9b09674

UR - http://www.scopus.com/inward/record.url?scp=85072848616&partnerID=8YFLogxK

U2 - 10.1021/acsami.9b09674

DO - 10.1021/acsami.9b09674

M3 - Article

VL - 11

SP - 35540

EP - 35547

JO - ACS Applied Materials and Interfaces

T2 - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

SN - 1944-8244

IS - 39

ER -