Electrochemical Monitoring of Singlet Oxygen Production

D Sharp, S Forsythe, J Davis

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials
    LanguageEnglish
    Pages2293-2296
    JournalElectroanalysis
    Volume21
    Issue number21
    DOIs
    Publication statusPublished - Nov 2009

    Fingerprint

    Singlet Oxygen
    Oxygen
    Monitoring
    Voltammetry
    Reactive Oxygen Species
    Degradation

    Keywords

    • Singlet oxygen
    • Diphenylisobenzofuran
    • Photosensitizer
    • Tetraphenylporphyrin
    • Square wave voltammetry
    • Voltammetry
    • Medicinal chemistry

    Cite this

    Sharp, D ; Forsythe, S ; Davis, J. / Electrochemical Monitoring of Singlet Oxygen Production. In: Electroanalysis. 2009 ; Vol. 21, No. 21. pp. 2293-2296.
    @article{c5c93b04d85c4d23be1ec4b17a8b978b,
    title = "Electrochemical Monitoring of Singlet Oxygen Production",
    abstract = "The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials",
    keywords = "Singlet oxygen, Diphenylisobenzofuran, Photosensitizer, Tetraphenylporphyrin, Square wave voltammetry, Voltammetry, Medicinal chemistry",
    author = "D Sharp and S Forsythe and J Davis",
    year = "2009",
    month = "11",
    doi = "10.1002/elan.200904682",
    language = "English",
    volume = "21",
    pages = "2293--2296",
    journal = "Electroanalysis",
    issn = "1040-0397",
    number = "21",

    }

    Electrochemical Monitoring of Singlet Oxygen Production. / Sharp, D; Forsythe, S; Davis, J.

    In: Electroanalysis, Vol. 21, No. 21, 11.2009, p. 2293-2296.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Electrochemical Monitoring of Singlet Oxygen Production

    AU - Sharp, D

    AU - Forsythe, S

    AU - Davis, J

    PY - 2009/11

    Y1 - 2009/11

    N2 - The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials

    AB - The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials

    KW - Singlet oxygen

    KW - Diphenylisobenzofuran

    KW - Photosensitizer

    KW - Tetraphenylporphyrin

    KW - Square wave voltammetry

    KW - Voltammetry

    KW - Medicinal chemistry

    U2 - 10.1002/elan.200904682

    DO - 10.1002/elan.200904682

    M3 - Article

    VL - 21

    SP - 2293

    EP - 2296

    JO - Electroanalysis

    T2 - Electroanalysis

    JF - Electroanalysis

    SN - 1040-0397

    IS - 21

    ER -