Electrochemical Monitoring of Singlet Oxygen Production

D Sharp, S Forsythe, J Davis

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials
    Original languageEnglish
    Pages (from-to)2293-2296
    JournalElectroanalysis
    Volume21
    Issue number21
    DOIs
    Publication statusPublished - Nov 2009

    Keywords

    • Singlet oxygen
    • Diphenylisobenzofuran
    • Photosensitizer
    • Tetraphenylporphyrin
    • Square wave voltammetry
    • Voltammetry
    • Medicinal chemistry

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