Electrochemical bubble rip: A new approach to controlled drug release

A Anderson; Aaron McConville; J Davis

doi:10.1016/j.elecom.2015.08.008

Electrochemical bubble rip: A new approach to controlled drug release

A Anderson
, Aaron McConville
, J Davis

Department of Employment and Learning (DEL)

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.

Original language	English
Pages (from-to)	88-91
Journal	Electrochemistry Communications
Volume	60
Early online date	14 Aug 2015
DOIs	https://doi.org/10.1016/j.elecom.2015.08.008
Publication status	Published (in print/issue) - 1 Nov 2015

Keywords

Electrode
Electrochemical
Drug release
MEMS
Methotrexate
Hydrogen

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10.1016/j.elecom.2015.08.008

Cite this

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title = "Electrochemical bubble rip: A new approach to controlled drug release",

abstract = "Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.",

keywords = "Electrode, Electrochemical, Drug release, MEMS, Methotrexate, Hydrogen",

author = "A Anderson and Aaron McConville and J Davis",

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journal = "Electrochemistry Communications",

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AU - McConville, Aaron

AU - Davis, J

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N2 - Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.

AB - Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.

KW - Electrode

KW - Electrochemical

KW - Drug release

KW - MEMS

KW - Methotrexate

KW - Hydrogen

UR - https://pure.ulster.ac.uk/en/publications/electrochemical-bubble-rip-a-new-approach-to-controlled-drug-rele-3

U2 - 10.1016/j.elecom.2015.08.008

DO - 10.1016/j.elecom.2015.08.008

M3 - Article

SN - 1388-2481

VL - 60

SP - 88

EP - 91

JO - Electrochemistry Communications

JF - Electrochemistry Communications

ER -

Electrochemical bubble rip: A new approach to controlled drug release

Abstract

Keywords

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Smart patch systems for controlled drug delivery and sensing applications

Tunable nanomaterials for controlled drug release in smart devices

Cite this

Electrochemical bubble rip: A new approach to controlled drug release

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Student theses

Smart patch systems for controlled drug delivery and sensing applications

Tunable nanomaterials for controlled drug release in smart devices

Cite this