Electrochemical bubble rip: A new approach to controlled drug release

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.
LanguageEnglish
Pages88-91
JournalElectrochemistry Communications
Volume60
Early online date14 Aug 2015
DOIs
Publication statusPublished - 1 Nov 2015

Fingerprint

Protective coatings
Electrolysis
Pharmaceutical Preparations
Coatings
Industry
cellulose acetate phthalate

Keywords

  • Electrode
  • Electrochemical
  • Drug release
  • MEMS
  • Methotrexate
  • Hydrogen

Cite this

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title = "Electrochemical bubble rip: A new approach to controlled drug release",
abstract = "Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.",
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Electrochemical bubble rip: A new approach to controlled drug release. / Anderson, A; McConville, Aaron; Davis, J.

In: Electrochemistry Communications, Vol. 60, 01.11.2015, p. 88-91.

Research output: Contribution to journalArticle

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AU - McConville, Aaron

AU - Davis, J

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AB - Cellulose acetate phthalate films are widely used as controlled release enteric coatings within the pharmaceutical industries but their properties have hitherto been unexplored within electrochemical devices. A novel approach employing controlled electrolysis has been investigated to develop a means through which the protective films can be compromised thereby enabling the release of candidate drugs. The generation of bubbles and local pH manipulation are considered and the former shown to enable rapid removal of the film and initiate reagent release.

KW - Electrode

KW - Electrochemical

KW - Drug release

KW - MEMS

KW - Methotrexate

KW - Hydrogen

UR - https://pure.ulster.ac.uk/en/publications/electrochemical-bubble-rip-a-new-approach-to-controlled-drug-rele-3

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M3 - Article

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T2 - Electrochemistry Communications

JF - Electrochemistry Communications

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