Electroanalytical sensor for diabetic foot ulcer monitoring with integrated electronics for connected health application

J Davis, Souradeep Roy, Shalini Nagabooshanam, Kushagra Krishna, Shikha Wadhwa, Nidhi Chauhan, Utkarsh Jain, Ranjit Kumar, Ashish Mathur

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

L-tyrosine is an amino acid, the concentration of which is found to be highly elevated in patients suffering from diabetic foot ulcer (DFU). The latter proves to be fatal when it turns out chronic and may lead to amputation. The conventional clinical diagnostic methods are costly and time consuming, in which case, the condition of patient(s) may deteriorate long before proper treatment commences. Herein, we report the development of smart band-aid for real time monitoring of L-tyrosine by employing enzymatic bio-sensor using α-MnO2/tyrosinase. The smart band-aid was further integrated with portable electronics capable of wireless data transmission to a personal digital assistant, and its tyrosine sensing perfor-mance was evaluated. Anodic current was found to vary linearly with the concentrations of L-tyrosine in the range of 5 nM – 500 μM. The developed sensor displayed a limit of detection and sensitivity of 0.71 nM and 0.67 µA/nM/mm2 re-spectively, with a stability of 25 days. The developed sensor was validated using a commercial impedance analyzer. The impedance response was found to be consistent with the cyclic voltammogram obtained and demonstrated to be a linear function of tyrosine concentration. The developed sensing platform combines early diagnosis with connected health tech-nologies, thus, fitting well into modern healthcare needs.
Original languageEnglish
Pages (from-to)2082-2089
Number of pages8
JournalElectroanalysis
Volume32
Issue number9
Early online date12 Jun 2020
DOIs
Publication statusPublished - 1 Sep 2020

Keywords

  • Diabetic foot ulcer
  • L-tyrosine
  • chemical sensor
  • electrocatalysis
  • manganese dioxide
  • smart band-aid

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    Davis, J., Roy, S., Nagabooshanam, S., Krishna, K., Wadhwa, S., Chauhan, N., Jain, U., Kumar, R., & Mathur, A. (2020). Electroanalytical sensor for diabetic foot ulcer monitoring with integrated electronics for connected health application. Electroanalysis, 32(9), 2082-2089. https://doi.org/10.1002/elan.201900665