Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

AMR Haro; A Smyth; P Hughes; CN Reid; Anthony McHale

doi:10.1016/j.canlet.2004.09.033

Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

AMR Haro, A Smyth, P Hughes, CN Reid, Anthony McHale

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14 Citations (Scopus)

Abstract

This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	49-55
Journal	Cancer Letters
Volume	222
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.09.033
Publication status	Published (in print/issue) - May 2005

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10.1016/j.canlet.2004.09.033

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title = "Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality",

abstract = "This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.",

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AU - Haro, AMR

AU - Smyth, A

AU - Hughes, P

AU - Reid, CN

AU - McHale, Anthony

PY - 2005/5

Y1 - 2005/5

N2 - This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.

AB - This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.canlet.2004.09.033

DO - 10.1016/j.canlet.2004.09.033

M3 - Article

VL - 222

SP - 49

EP - 55

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

Abstract

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