Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

AMR Haro, A Smyth, P Hughes, CN Reid, Anthony McHale

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)49-55
JournalCancer Letters
Volume222
Issue number1
DOIs
Publication statusPublished - May 2005

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