Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

AMR Haro, A Smyth, P Hughes, CN Reid, Anthony McHale

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.
LanguageEnglish
Pages49-55
JournalCANCER LETTERS
Volume222
Issue number1
DOIs
Publication statusPublished - May 2005

Fingerprint

Neoplasms
Ireland
Erythrocytes
Therapeutics
Growth
Pharmaceutical Preparations
In Vitro Techniques

Cite this

Haro, AMR ; Smyth, A ; Hughes, P ; Reid, CN ; McHale, Anthony. / Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality. 2005 ; Vol. 222, No. 1. pp. 49-55.
@article{ee8ba26988424b098e5606d80e6198f4,
title = "Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality",
abstract = "This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.",
author = "AMR Haro and A Smyth and P Hughes and CN Reid and Anthony McHale",
year = "2005",
month = "5",
doi = "10.1016/j.canlet.2004.09.033",
language = "English",
volume = "222",
pages = "49--55",
number = "1",

}

Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality. / Haro, AMR; Smyth, A; Hughes, P; Reid, CN; McHale, Anthony.

Vol. 222, No. 1, 05.2005, p. 49-55.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

AU - Haro, AMR

AU - Smyth, A

AU - Hughes, P

AU - Reid, CN

AU - McHale, Anthony

PY - 2005/5

Y1 - 2005/5

N2 - This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.

AB - This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer. (c) 2004, Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.canlet.2004.09.033

DO - 10.1016/j.canlet.2004.09.033

M3 - Article

VL - 222

SP - 49

EP - 55

IS - 1

ER -