Efficacy of resveratrol encapsulated microsponges delivered by pectin based matrix tablets in rats with acetic acid-induced ulcerative colitis

Himanshu Gandhi, Charul Rathore, Kamal Dua, Samar Vihal, Murtaza M. Tambuwala, Poonam Negi

Research output: Contribution to journalArticle

Abstract

Objectives: The objective of the present work to encapsulate the resveratrol (RES) inside the chitosan-based microsponges, employing the systematic optimization by 3 3 Box–Behnken design for the colonic targeting. Significance: Enhanced therapeutic efficacy of RES-loaded microsponges and matrix tablets, vis-a-vis pureRES for ulcerative colitis. Methods: RES-loaded microsponges were prepared employing the systematic optimization by 3 3 Box–Behnken design for the colonic targeting. The best-optimizedRES-loaded microsponge was compressed in the form of a tablet, employing pectin as a matrix-forming material. The encapsulation of RES inside microsponge was confirmed by XRD, DSC and FT-IR. Further, both RES-loaded microsponges and matrix tablets were evaluated for in vitro release kinetics and further evaluated for in vivo ulcerative colitis animal model. Results: Optimization experiments was obtained as the high value of r 2 (particle size = 0.9999; %EE = 0.9652; %CDR = 0.9469) inferred excellent goodness of fit. SEM revealed nearly spherical and porous nature of RES-loaded microsponges. The in vitro release kinetic showed zero-order release for RES-loaded microsponges and Korsmeyer–Peppas model for matrix tablets. The pharmacodynamic studies, in ulcerative colitis rat model, indicated better therapeutic efficacy of drug-loaded microsponges and matrix tablets, vis-a-vis pure RES. Thus, the present study advocates the potential of RES based microsponges delivered by pectin based matrix tablet, in the treatment of various colonic disorders. Conclusion: The present study proved that RES-loaded microsponges and matrix tablets based on chitosan and pectin can be the ideal delivery system for colonic delivery of RES.

Original languageEnglish
Pages (from-to)365-375
Number of pages11
JournalDrug Development and Industrial Pharmacy
Volume46
Issue number3
Early online date10 Feb 2020
DOIs
Publication statusPublished - 3 Mar 2020

Keywords

  • Box–Behnken design
  • Chitosan
  • pectin
  • quasi emulsion solvent diffusion method
  • release kinetics
  • ulcerative colitis

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