Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in Microfluidic Lab-On-A-Chip systems for bioengineering applications

Subhadeep Mukhopadhyay, Jyoti Prasad Banerjee, Susanta Sinha Roy, Sanjeev Kumar Metya, Mark Tweedie, James Andrew Mclaughlin

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    In this research paper, in total 212 individual leakage-free Polymethylmethacrylate (PMMA) microfluidic devices are fabricated by maskless lithography, hot embossing lithography and direct bonding technique. The effect of channel aspect ratio on dyed water flow is investigated using these microfluidic devices. Experimental studies show that the dyed water flow is faster on the surface of higher wettability. The effect of capillary pressure on dyed water flow is studied in the fabricated PMMA microfluidic devices. According to the experimental observations, the centrifugal force has prominent effect on the dyed water flow. Also, the effect of bend angle is investigated on the surface-driven capillary flow of water. The polystyrene microparticles have been separated in the microfluidic lab-on-a-chip systems using the investigated flow features. A 100% separation efficiency is achieved in these lab-on-a-chip systems. These microfluidic lab-on-a-chip systems can be used to separate blood cells from human whole blood for further clinical tests. These experimental studies are important in bioengineering applications. The effect of bend angle as channel geometry to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems. Also, the effect of surface wettability as surface property to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems.

    Original languageEnglish
    Article number1750041
    JournalSurface Review and Letters
    Volume24
    Issue number3
    DOIs
    Publication statusPublished - 1 Apr 2017

    Keywords

    • capillary flow
    • Hot embossing
    • microfluidic device
    • surface wettability

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