Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Nigel Irwin, Victor Gault, BD Green, B Greer, Janie McCluskey, P Harriott, Finbarr O'Harte, Peter Flatt

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Glucose dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p
LanguageEnglish
Pages845-852
JournalBiological Chemistry
Volume385
Issue number9
DOIs
Publication statusPublished - Sep 2004

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Homeostasis
Insulin
Glucose
Body Weight
Incretins
Peptides
Eating
Hormones
Food
Injections
gastric inhibitory polypeptide receptor
Pro(3)-glucose-dependent insulinotropic polypeptide

Cite this

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Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice. / Irwin, Nigel; Gault, Victor; Green, BD; Greer, B; McCluskey, Janie; Harriott, P; O'Harte, Finbarr; Flatt, Peter.

In: Biological Chemistry, Vol. 385, No. 9, 09.2004, p. 845-852.

Research output: Contribution to journalArticle

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AU - Irwin, Nigel

AU - Gault, Victor

AU - Green, BD

AU - Greer, B

AU - McCluskey, Janie

AU - Harriott, P

AU - O'Harte, Finbarr

AU - Flatt, Peter

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AB - Glucose dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p

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DO - 10.1515/BC.2004.110

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T2 - Biological Chemistry

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