Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Nigel Irwin, Victor Gault, BD Green, B Greer, Janie McCluskey, P Harriott, Finbarr O'Harte, Peter Flatt

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Glucose dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p
Original languageEnglish
Pages (from-to)845-852
JournalBiological Chemistry
Volume385
Issue number9
DOIs
Publication statusPublished - Sep 2004

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