Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Nigel Irwin; Victor Gault; BD Green; B Greer; Janie McCluskey; P Harriott; Finbarr O'Harte; Peter Flatt

doi:10.1515/BC.2004.110

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Nigel Irwin, Victor Gault, BD Green, B Greer, Janie McCluskey, P Harriott, Finbarr O'Harte, Peter Flatt

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Abstract

Glucose dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p

Original language	English
Pages (from-to)	845-852
Journal	Biological Chemistry
Volume	385
Issue number	9
DOIs	https://doi.org/10.1515/BC.2004.110
Publication status	Published (in print/issue) - Sept 2004

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10.1515/BC.2004.110

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AU - O'Harte, Finbarr

AU - Flatt, Peter

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Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Abstract

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