Effects of short-term chemical ablation of glucagon signaling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

ZJ Franklin; Finbarr O'Harte; Nigel Irwin

doi:10.1515/hsz-2013-0224

Effects of short-term chemical ablation of glucagon signaling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

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Abstract

Glucagon is a hormone with important effects on blood glucose regulation. This study hasutilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon anddesHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibition ofglucagon receptor signalling in normal mice. Twice-daily injection of either analogue for10 days had no effect on food intake, body weight and non-fasting plasma glucoseconcentrations. However, insulin levels were significantly raised (P

Original language	English
Pages (from-to)	433-442
Journal	Biological Chemistry
Volume	395
Issue number	4
DOIs	https://doi.org/10.1515/hsz-2013-0224
Publication status	Published (in print/issue) - 1 Apr 2014

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SDG 3 Good Health and Well-being

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10.1515/hsz-2013-0224

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abstract = "Glucagon is a hormone with important effects on blood glucose regulation. This study hasutilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon anddesHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibition ofglucagon receptor signalling in normal mice. Twice-daily injection of either analogue for10 days had no effect on food intake, body weight and non-fasting plasma glucoseconcentrations. However, insulin levels were significantly raised (P",

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Effects of short-term chemical ablation of glucagon signaling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

Abstract

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