Effects of short-term chemical ablation of glucagon signaling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

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Abstract

Glucagon is a hormone with important effects on blood glucose regulation. This study hasutilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon anddesHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibition ofglucagon receptor signalling in normal mice. Twice-daily injection of either analogue for10 days had no effect on food intake, body weight and non-fasting plasma glucoseconcentrations. However, insulin levels were significantly raised (P
LanguageEnglish
Pages433-442
JournalBiological Chemistry
Volume395
Issue number4
DOIs
Publication statusPublished - 1 Apr 2014

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Insulin Antagonists
Glucagon Receptors
Ablation
Glucagon
Homeostasis
Insulin
Glucose
Peptides
Blood Glucose
Eating
Body Weight
Hormones
Plasmas
Injections

Cite this

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abstract = "Glucagon is a hormone with important effects on blood glucose regulation. This study hasutilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon anddesHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibition ofglucagon receptor signalling in normal mice. Twice-daily injection of either analogue for10 days had no effect on food intake, body weight and non-fasting plasma glucoseconcentrations. However, insulin levels were significantly raised (P",
author = "ZJ Franklin and Finbarr O'Harte and Nigel Irwin",
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AU - O'Harte, Finbarr

AU - Irwin, Nigel

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N2 - Glucagon is a hormone with important effects on blood glucose regulation. This study hasutilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon anddesHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibition ofglucagon receptor signalling in normal mice. Twice-daily injection of either analogue for10 days had no effect on food intake, body weight and non-fasting plasma glucoseconcentrations. However, insulin levels were significantly raised (P

AB - Glucagon is a hormone with important effects on blood glucose regulation. This study hasutilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon anddesHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibition ofglucagon receptor signalling in normal mice. Twice-daily injection of either analogue for10 days had no effect on food intake, body weight and non-fasting plasma glucoseconcentrations. However, insulin levels were significantly raised (P

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