Effects of reinforcement schedule on facilitation of operant extinction by chlordiazepoxide

Julian Leslie, David Shaw, G Gregg, N McCormick, DS Reynolds, GR Dawson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Learning and memory are central topics in behavioral neuroscience, and inbred mice strains are widely investigated. However, operant conditioning techniques are not as extensively used in this field as they should be, given the effectiveness of the methodology of the experimental analysis of behavior. In the present study, male C57B1/6 mice, widely used as background for transgenic studies, were trained to lever press on discrete-trial fixed-ratio 5 or fixed-interval (11 s or 31 s) schedules of food reinforcement and then exposed to 15 extinction sessions following vehicle or chlordiazepoxide injections (15 mg/kg i.p., administered either prior to all extinction sessions, or prior to the final 10 extinction sessions). Extinction of operant behavior was facilitated by drug administration following training on either schedule, but this facilitation only occurred once a number of extinction sessions had taken place. The extinction process proceeded more rapidly following fixed-interval training. Resistance to extinction was equally high following training with either schedule type, and was reduced by drug administration in both cases. These phenomena were evident in individual Cumulative records and in analyses of group data. Results are interpreted in terms of phenomena of operant extinction identified in Skinner's (1938) Behavior of organisms, and by behavioral momentum theory. These procedures could be used to extend the contribution of operant conditioning to contemporary behavioral neuroscience.
LanguageEnglish
Pages327-338
JournalJournal of the Experimental Analysis of Behavior
Volume84
Issue number3
DOIs
Publication statusPublished - Nov 2005

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Reinforcement Schedule
Chlordiazepoxide
Operant Conditioning
Neurosciences
Appointments and Schedules
Inbred Strains Mice
Psychological Extinction
Pharmaceutical Preparations
Learning
Food
Injections

Cite this

Leslie, Julian ; Shaw, David ; Gregg, G ; McCormick, N ; Reynolds, DS ; Dawson, GR. / Effects of reinforcement schedule on facilitation of operant extinction by chlordiazepoxide. In: Journal of the Experimental Analysis of Behavior. 2005 ; Vol. 84, No. 3. pp. 327-338.
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Effects of reinforcement schedule on facilitation of operant extinction by chlordiazepoxide. / Leslie, Julian; Shaw, David; Gregg, G; McCormick, N; Reynolds, DS; Dawson, GR.

In: Journal of the Experimental Analysis of Behavior, Vol. 84, No. 3, 11.2005, p. 327-338.

Research output: Contribution to journalArticle

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