Effects of linalool on extinction of mouse operant behaviour: Linalool and operant extinction

D Shaw, Kelly Norwood, Paul J. Kennedy, J.C. Leslie

Research output: Contribution to journalArticle

Abstract

Linalool is an enanitomer monoterpene compound identified as the pharmacologically active constituent in a number of essential oils and has been reported to display anxiolytic properties in humans and in animal models and to exert both GABAergic and glutamatergic effects. In Experiment 1 linalool (100, 200, and 300, i.p.) had no significant effects compared with saline in an activity tracker with C57BL/6j mice. Experiment 2 assessed the effects on operant extinction with mice of chlordiazepoxide at a dose (15 mg/kg, i.p.) previously shown to facilitate extinction, and the same doses of linalool, compared with saline. Linalool had a dose-related facilitatory effect on extinction. While the effects of the highest dose of linalool most closely resembled the effects of chlordiazepoxide, the pattern of results suggested that linalool may affect both the acquisition of extinction learning, which is influenced by glutamatergic processes, and the expression of extinction, known to be affected by GABAergic agents such as chlordiazepoxide.

LanguageEnglish
Article numberBP-19-27R1
Pages73-80
Number of pages8
JournalBehavioural Pharmacology
Volume31
Issue number1
DOIs
Publication statusPublished - 1 Feb 2020

Fingerprint

Chlordiazepoxide
GABA Agents
Monoterpenes
Anti-Anxiety Agents
Volatile Oils
Inbred C57BL Mouse
Psychological Extinction
linalool
Animal Models
Learning

Keywords

  • Linalool
  • Chlordiazepoxide
  • Operant behaviour
  • Extinction

Cite this

@article{c6a0275a37ea44ffa08a94c60dec0638,
title = "Effects of linalool on extinction of mouse operant behaviour: Linalool and operant extinction",
abstract = "Linalool is an enanitomer monoterpene compound identified as the pharmacologically active constituent in a number of essential oils and has been reported to display anxiolytic properties in humans and in animal models and to exert both GABAergic and glutamatergic effects. In Experiment 1 linalool (100, 200, and 300, i.p.) had no significant effects compared with saline in an activity tracker with C57BL/6j mice. Experiment 2 assessed the effects on operant extinction with mice of chlordiazepoxide at a dose (15 mg/kg, i.p.) previously shown to facilitate extinction, and the same doses of linalool, compared with saline. Linalool had a dose-related facilitatory effect on extinction. While the effects of the highest dose of linalool most closely resembled the effects of chlordiazepoxide, the pattern of results suggested that linalool may affect both the acquisition of extinction learning, which is influenced by glutamatergic processes, and the expression of extinction, known to be affected by GABAergic agents such as chlordiazepoxide.",
keywords = "Linalool, Chlordiazepoxide, Operant behaviour, Extinction",
author = "D Shaw and Kelly Norwood and Kennedy, {Paul J.} and J.C. Leslie",
note = "This paper is dedicated to the memory of our friend and colleague, David Shaw (1970-2017).",
year = "2020",
month = "2",
day = "1",
doi = "10.1097/FBP.0000000000000511",
language = "English",
volume = "31",
pages = "73--80",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
number = "1",

}

Effects of linalool on extinction of mouse operant behaviour : Linalool and operant extinction . / Shaw, D; Norwood, Kelly; Kennedy, Paul J.; Leslie, J.C.

In: Behavioural Pharmacology, Vol. 31, No. 1, BP-19-27R1, 01.02.2020, p. 73-80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of linalool on extinction of mouse operant behaviour

T2 - Behavioural Pharmacology

AU - Shaw, D

AU - Norwood, Kelly

AU - Kennedy, Paul J.

AU - Leslie, J.C.

N1 - This paper is dedicated to the memory of our friend and colleague, David Shaw (1970-2017).

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Linalool is an enanitomer monoterpene compound identified as the pharmacologically active constituent in a number of essential oils and has been reported to display anxiolytic properties in humans and in animal models and to exert both GABAergic and glutamatergic effects. In Experiment 1 linalool (100, 200, and 300, i.p.) had no significant effects compared with saline in an activity tracker with C57BL/6j mice. Experiment 2 assessed the effects on operant extinction with mice of chlordiazepoxide at a dose (15 mg/kg, i.p.) previously shown to facilitate extinction, and the same doses of linalool, compared with saline. Linalool had a dose-related facilitatory effect on extinction. While the effects of the highest dose of linalool most closely resembled the effects of chlordiazepoxide, the pattern of results suggested that linalool may affect both the acquisition of extinction learning, which is influenced by glutamatergic processes, and the expression of extinction, known to be affected by GABAergic agents such as chlordiazepoxide.

AB - Linalool is an enanitomer monoterpene compound identified as the pharmacologically active constituent in a number of essential oils and has been reported to display anxiolytic properties in humans and in animal models and to exert both GABAergic and glutamatergic effects. In Experiment 1 linalool (100, 200, and 300, i.p.) had no significant effects compared with saline in an activity tracker with C57BL/6j mice. Experiment 2 assessed the effects on operant extinction with mice of chlordiazepoxide at a dose (15 mg/kg, i.p.) previously shown to facilitate extinction, and the same doses of linalool, compared with saline. Linalool had a dose-related facilitatory effect on extinction. While the effects of the highest dose of linalool most closely resembled the effects of chlordiazepoxide, the pattern of results suggested that linalool may affect both the acquisition of extinction learning, which is influenced by glutamatergic processes, and the expression of extinction, known to be affected by GABAergic agents such as chlordiazepoxide.

KW - Linalool

KW - Chlordiazepoxide

KW - Operant behaviour

KW - Extinction

UR - http://www.scopus.com/inward/record.url?scp=85077782926&partnerID=8YFLogxK

U2 - 10.1097/FBP.0000000000000511

DO - 10.1097/FBP.0000000000000511

M3 - Article

VL - 31

SP - 73

EP - 80

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 1

M1 - BP-19-27R1

ER -