Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves

R Zabielski, Violetta Naughton, J Borlak, PC Gregory, P Kiela, SG Pierzynowski, W Barej

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Abstract

The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide+/-atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms. (C) 1998 Elsevier Science B.V. All rights reserved.
LanguageEnglish
Pages113-123
JournalRegulatory Peptides
Volume78
Issue number1-3
Publication statusPublished - Nov 1998

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Atropine
Sincalide
Cholecystokinin A Receptor
Proteins
Pancreatic Ducts
Bicarbonates
Electrodes
Milk
Catheters
Head
tarazepide

Cite this

Zabielski, R., Naughton, V., Borlak, J., Gregory, PC., Kiela, P., Pierzynowski, SG., & Barej, W. (1998). Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. 78(1-3), 113-123.
Zabielski, R ; Naughton, Violetta ; Borlak, J ; Gregory, PC ; Kiela, P ; Pierzynowski, SG ; Barej, W. / Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. 1998 ; Vol. 78, No. 1-3. pp. 113-123.
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Zabielski, R, Naughton, V, Borlak, J, Gregory, PC, Kiela, P, Pierzynowski, SG & Barej, W 1998, 'Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves', vol. 78, no. 1-3, pp. 113-123.

Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. / Zabielski, R; Naughton, Violetta; Borlak, J; Gregory, PC; Kiela, P; Pierzynowski, SG; Barej, W.

Vol. 78, No. 1-3, 11.1998, p. 113-123.

Research output: Contribution to journalArticle

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AU - Zabielski, R

AU - Naughton, Violetta

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AU - Pierzynowski, SG

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N2 - The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide+/-atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms. (C) 1998 Elsevier Science B.V. All rights reserved.

AB - The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide+/-atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms. (C) 1998 Elsevier Science B.V. All rights reserved.

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Zabielski R, Naughton V, Borlak J, Gregory PC, Kiela P, Pierzynowski SG et al. Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. 1998 Nov;78(1-3):113-123.