TY - JOUR
T1 - Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells
AU - Hawthorne, S.
AU - Gallagher, S.
N1 - cited By 23
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Glycyrrhetinic acid (GA) is the active metabolite of glycyrrhizic acid, one of the components of liquorice extract. It has been shown to possess anti‐inflammatory activity and to inhibit hepatic tumour growth. In this preliminary study, we have shown that GA could significantly reduce the rate of proliferation of LNCaP androgen dependent prostate cancer cells, whereas it had no effect on proliferation of PC3 and DU145 androgen‐independent prostate cancer cells. Additionally, GA could significantly reduce the production of prostate‐specific antigen by LNCaP cells maintained in‐vitro. This study provides a sound platform for further investigation.
AB - Glycyrrhetinic acid (GA) is the active metabolite of glycyrrhizic acid, one of the components of liquorice extract. It has been shown to possess anti‐inflammatory activity and to inhibit hepatic tumour growth. In this preliminary study, we have shown that GA could significantly reduce the rate of proliferation of LNCaP androgen dependent prostate cancer cells, whereas it had no effect on proliferation of PC3 and DU145 androgen‐independent prostate cancer cells. Additionally, GA could significantly reduce the production of prostate‐specific antigen by LNCaP cells maintained in‐vitro. This study provides a sound platform for further investigation.
UR - https://www.scopus.com/pages/publications/42549126384
U2 - 10.1211/jpp.60.5.0013
DO - 10.1211/jpp.60.5.0013
M3 - Article
SN - 2042-7158
VL - 60
SP - 661
EP - 666
JO - JOURNAL OF PHARMACY AND PHARMACOLOGY
JF - JOURNAL OF PHARMACY AND PHARMACOLOGY
IS - 5
ER -
