Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Ankur Sharma; Susan Hawthorne; Saurabh Jha; Niraj Jha; Dhruv Kumar; Samuel Girgis; Vineet Goswami; Gaurav Gupta; Sachin Singh; Harish Dureja; Dinesh Chellappan; Kamal Dua

doi:10.2217/nnm-2021-0066

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Ankur Sharma
, Susan Hawthorne
, Saurabh Jha
, Niraj Jha
, Dhruv Kumar
, Samuel Girgis
, Vineet Goswami
, Gaurav Gupta
, Sachin Singh
, Harish Dureja
, Dinesh Chellappan
, Kamal Dua

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

109 Downloads (Pure)

Abstract

Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

Original language	English
Pages (from-to)	1763-1773
Number of pages	11
Journal	NANOMEDICINE
Volume	16
Issue number	20
Early online date	23 Jun 2021
DOIs	https://doi.org/10.2217/nnm-2021-0066
Publication status	Published (in print/issue) - 23 Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 Future Medicine Ltd.. All rights reserved.

Funding

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.2217/nnm-2021-0066Licence: CC BY

nnm-2021-0066Final published version, 2.88 MBLicence: CC BY

Cite this

@article{54905f36b4084e1bac5955e899f7a42c,

title = "Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells",

abstract = "Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.",

author = "Ankur Sharma and Susan Hawthorne and Saurabh Jha and Niraj Jha and Dhruv Kumar and Samuel Girgis and Vineet Goswami and Gaurav Gupta and Sachin Singh and Harish Dureja and Dinesh Chellappan and Kamal Dua",

year = "2021",

month = jul,

day = "23",

doi = "10.2217/nnm-2021-0066",

language = "English",

volume = "16",

pages = "1763--1773",

journal = "NANOMEDICINE",

issn = "1743-5889",

publisher = "Taylor \& Francis",

number = "20",

}

TY - JOUR

T1 - Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

AU - Sharma, Ankur

AU - Hawthorne, Susan

AU - Jha, Saurabh

AU - Jha, Niraj

AU - Kumar, Dhruv

AU - Girgis, Samuel

AU - Goswami, Vineet

AU - Gupta, Gaurav

AU - Singh, Sachin

AU - Dureja, Harish

AU - Chellappan, Dinesh

AU - Dua, Kamal

PY - 2021/7/23

Y1 - 2021/7/23

N2 - Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

AB - Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

UR - https://www.scopus.com/pages/publications/85112197303

U2 - 10.2217/nnm-2021-0066

DO - 10.2217/nnm-2021-0066

M3 - Article

C2 - 34296625

SN - 1743-5889

VL - 16

SP - 1763

EP - 1773

JO - NANOMEDICINE

JF - NANOMEDICINE

IS - 20

ER -

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this