Effects of biosurfactants on antibiotic challenged Salmonella typhimurium and Staphylococcus aureus

Research output: Contribution to conferenceAbstractpeer-review


Aims:To determine whether the presence of biosurfactants make Salmonella typhimurium and Staphylococcus aureus strains more susceptible to antibiotic challenge.
Methods and results: Testing was, carried out by monitoring the effects of biosurfactants at different concentrations on several strains and with different antibiotic concentrations (1). The results show that when certain antibiotics are used in the presence of these biosurfactants at low concentration an inhibitory effect occurs, however when the concentration of biosurfactant is increased the antibiotic inhibitory effects are negated allowing bacterial isolates to grow more effectively than the control.
Further investigation is required to elucidate the mechanisms behind these effects.
Significance of study
In the past two decades, there have been increased concerns over the emergence of bacterial multiple drug resistance against most of the drugs available in the market today. The effect is collectively termed antimicrobial resistance (AMR) and is, displayed by some of the common strains that cause infections in humans including Salmonella typhimurium and Staphylococcus aureus. The search to combat AMR has led to investigation of the use of bioactive products derived from microorganisms such as surface-active components (biosurfactants), (2). These biosurfactants are nontoxic, biodegradable and have different effects when added to various bacterial strains. Some of these effects, according to the type of molecule, reduce bacterial proliferation (3).
(1) Elshikh M, Ahmed S, Funston S, Dunlop P, McGaw M, Marchant R and Banat I (2016). Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants. Biotechnol. Lett.38, 1015-1019.
(2) Banat I, De Rienzo M and Quinn, G (2014). Microbial biofilms: biosurfactants as antibiofilm agents. Appl. Microbiol. Biotechnol.98, 9915-9929.
(3) Banat IM, Makkar SR and Cameotra SS (2000). Potential commercial application of microbial surfactants. A review article. Appl. Microbiol. Biotechnol. 53,495-508.
Original languageEnglish
Publication statusPublished (in print/issue) - 14 Nov 2018
EventSFAM Antimicrobial Resistance Conference 2018: Beyond the microbiological - Charles Darwin House, London, United Kingdom
Duration: 14 Nov 201814 Nov 2018


ConferenceSFAM Antimicrobial Resistance Conference 2018
Country/TerritoryUnited Kingdom


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