Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study

F Intorre, A Polito, M Andriollo-Sanchez, E Azzini, A Raguzzini, E Toti, M Zaccaria, G Catasta, N Meunier, V Ducros, JM O'Connor, C Coudray, AM Roussel, G Maiani

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Abstract

Objective: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. Subjects/Methods: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. Results: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. Conclusions: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.
LanguageEnglish
Pages1215-1223
JournalEuropean Journal of Clinical Nutrition
Volume62
Issue number10
DOIs
Publication statusPublished - Oct 2008

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Vitamins
Zinc
Erythrocytes
Vitamin A
Folic Acid
Vitamin E
Placebos
alpha-Tocopherol
Luminescence
Immunoassay
Volunteers
Fasting
Cholesterol
High Pressure Liquid Chromatography
Serum

Cite this

Intorre, F., Polito, A., Andriollo-Sanchez, M., Azzini, E., Raguzzini, A., Toti, E., ... Maiani, G. (2008). Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. European Journal of Clinical Nutrition, 62(10), 1215-1223. https://doi.org/10.1038/sj.ejcn.1602844
Intorre, F ; Polito, A ; Andriollo-Sanchez, M ; Azzini, E ; Raguzzini, A ; Toti, E ; Zaccaria, M ; Catasta, G ; Meunier, N ; Ducros, V ; O'Connor, JM ; Coudray, C ; Roussel, AM ; Maiani, G. / Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. In: European Journal of Clinical Nutrition. 2008 ; Vol. 62, No. 10. pp. 1215-1223.
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abstract = "Objective: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. Subjects/Methods: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. Results: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. Conclusions: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.",
author = "F Intorre and A Polito and M Andriollo-Sanchez and E Azzini and A Raguzzini and E Toti and M Zaccaria and G Catasta and N Meunier and V Ducros and JM O'Connor and C Coudray and AM Roussel and G Maiani",
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Intorre, F, Polito, A, Andriollo-Sanchez, M, Azzini, E, Raguzzini, A, Toti, E, Zaccaria, M, Catasta, G, Meunier, N, Ducros, V, O'Connor, JM, Coudray, C, Roussel, AM & Maiani, G 2008, 'Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study', European Journal of Clinical Nutrition, vol. 62, no. 10, pp. 1215-1223. https://doi.org/10.1038/sj.ejcn.1602844

Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. / Intorre, F; Polito, A; Andriollo-Sanchez, M; Azzini, E; Raguzzini, A; Toti, E; Zaccaria, M; Catasta, G; Meunier, N; Ducros, V; O'Connor, JM; Coudray, C; Roussel, AM; Maiani, G.

In: European Journal of Clinical Nutrition, Vol. 62, No. 10, 10.2008, p. 1215-1223.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study

AU - Intorre, F

AU - Polito, A

AU - Andriollo-Sanchez, M

AU - Azzini, E

AU - Raguzzini, A

AU - Toti, E

AU - Zaccaria, M

AU - Catasta, G

AU - Meunier, N

AU - Ducros, V

AU - O'Connor, JM

AU - Coudray, C

AU - Roussel, AM

AU - Maiani, G

PY - 2008/10

Y1 - 2008/10

N2 - Objective: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. Subjects/Methods: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. Results: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. Conclusions: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.

AB - Objective: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. Subjects/Methods: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. Results: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. Conclusions: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.

U2 - 10.1038/sj.ejcn.1602844

DO - 10.1038/sj.ejcn.1602844

M3 - Article

VL - 62

SP - 1215

EP - 1223

JO - European Journal of Clinical Nutrition

T2 - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 10

ER -