Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study

Clare F Hodkinson, Mary McCann, H Denis Alexander, Ian Bradbury, Paula J Robson, Maxine P Bonham, Jacqueline O'Connor, Charles Coudray, JJ Strain, Julie Wallace

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Abstract

Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship between Zn status and markers of immunity and the effect of supplementation with 15 mg or 30 mg Zn/d for 6 months on immune status in healthy individuals. Zn status was assessed by dietary intake and biochemical indices. Immune status was assessed by multiple flow cytometric methods. At baseline, Zn concentration was positively associated with lymphocyte subpopulation counts and T-lymphocyte activation. Zn supplementation of 30 mg/d significantly lowered B-lymphocyte count, albeit at month 3 only. Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6. Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55-70 years.
LanguageEnglish
Pages598-608
JournalJournals of Gerontology, Series A
Volume62
Issue number6
Publication statusPublished - Jun 2007

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Zinc
Lymphocyte Count
T-Lymphocytes
CD4-CD8 Ratio
Lymphocyte Subsets
Lymphocyte Activation
Immune System
Immunity
B-Lymphocytes
Diet

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Hodkinson, C. F., McCann, M., Alexander, H. D., Bradbury, I., Robson, P. J., Bonham, M. P., ... Wallace, J. (2007). Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study. Journals of Gerontology, Series A, 62(6), 598-608.
Hodkinson, Clare F ; McCann, Mary ; Alexander, H Denis ; Bradbury, Ian ; Robson, Paula J ; Bonham, Maxine P ; O'Connor, Jacqueline ; Coudray, Charles ; Strain, JJ ; Wallace, Julie. / Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study. In: Journals of Gerontology, Series A. 2007 ; Vol. 62, No. 6. pp. 598-608.
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abstract = "Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship between Zn status and markers of immunity and the effect of supplementation with 15 mg or 30 mg Zn/d for 6 months on immune status in healthy individuals. Zn status was assessed by dietary intake and biochemical indices. Immune status was assessed by multiple flow cytometric methods. At baseline, Zn concentration was positively associated with lymphocyte subpopulation counts and T-lymphocyte activation. Zn supplementation of 30 mg/d significantly lowered B-lymphocyte count, albeit at month 3 only. Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6. Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55-70 years.",
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Hodkinson, CF, McCann, M, Alexander, HD, Bradbury, I, Robson, PJ, Bonham, MP, O'Connor, J, Coudray, C, Strain, JJ & Wallace, J 2007, 'Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study', Journals of Gerontology, Series A, vol. 62, no. 6, pp. 598-608.

Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study. / Hodkinson, Clare F; McCann, Mary; Alexander, H Denis; Bradbury, Ian; Robson, Paula J; Bonham, Maxine P; O'Connor, Jacqueline; Coudray, Charles; Strain, JJ; Wallace, Julie.

In: Journals of Gerontology, Series A, Vol. 62, No. 6, 06.2007, p. 598-608.

Research output: Contribution to journalArticle

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AU - Strain, JJ

AU - Wallace, Julie

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