Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study

C Feillet-Coudray, N Meunier, D Bayle, M Brandolini-Bunlon, M Andriollo-Sanchez, JM O'Connor, G Maiani, AM Roussel, A Mazur, C Coudray

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Abstract

Zn has been shown to possess antioxidant properties in vitro and in vivo. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women. Three groups of sixteen healthy subjects aged 55-70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30 mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4 d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E status were also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55-70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions.
LanguageEnglish
Pages1134-1142
JournalBRITISH JOURNAL OF NUTRITION
Volume95
Issue number6
DOIs
Publication statusPublished - Jun 2006

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LDL Lipoproteins
Zinc
Copper
Healthy Volunteers
Vitamin E
Population
Dietary Supplements
Sex Characteristics
Disease Progression
In Vitro Techniques
Oxidative Stress
Eating
Antioxidants
Placebos
Lipids
oxidized low density lipoprotein
Serum

Cite this

Feillet-Coudray, C., Meunier, N., Bayle, D., Brandolini-Bunlon, M., Andriollo-Sanchez, M., O'Connor, JM., ... Coudray, C. (2006). Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study. BRITISH JOURNAL OF NUTRITION, 95(6), 1134-1142. https://doi.org/10.1079/BJN20061762
Feillet-Coudray, C ; Meunier, N ; Bayle, D ; Brandolini-Bunlon, M ; Andriollo-Sanchez, M ; O'Connor, JM ; Maiani, G ; Roussel, AM ; Mazur, A ; Coudray, C. / Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study. In: BRITISH JOURNAL OF NUTRITION. 2006 ; Vol. 95, No. 6. pp. 1134-1142.
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abstract = "Zn has been shown to possess antioxidant properties in vitro and in vivo. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women. Three groups of sixteen healthy subjects aged 55-70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30 mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4 d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E status were also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55-70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions.",
author = "C Feillet-Coudray and N Meunier and D Bayle and M Brandolini-Bunlon and M Andriollo-Sanchez and JM O'Connor and G Maiani and AM Roussel and A Mazur and C Coudray",
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Feillet-Coudray, C, Meunier, N, Bayle, D, Brandolini-Bunlon, M, Andriollo-Sanchez, M, O'Connor, JM, Maiani, G, Roussel, AM, Mazur, A & Coudray, C 2006, 'Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study', BRITISH JOURNAL OF NUTRITION, vol. 95, no. 6, pp. 1134-1142. https://doi.org/10.1079/BJN20061762

Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study. / Feillet-Coudray, C; Meunier, N; Bayle, D; Brandolini-Bunlon, M; Andriollo-Sanchez, M; O'Connor, JM; Maiani, G; Roussel, AM; Mazur, A; Coudray, C.

In: BRITISH JOURNAL OF NUTRITION, Vol. 95, No. 6, 06.2006, p. 1134-1142.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study

AU - Feillet-Coudray, C

AU - Meunier, N

AU - Bayle, D

AU - Brandolini-Bunlon, M

AU - Andriollo-Sanchez, M

AU - O'Connor, JM

AU - Maiani, G

AU - Roussel, AM

AU - Mazur, A

AU - Coudray, C

PY - 2006/6

Y1 - 2006/6

N2 - Zn has been shown to possess antioxidant properties in vitro and in vivo. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women. Three groups of sixteen healthy subjects aged 55-70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30 mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4 d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E status were also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55-70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions.

AB - Zn has been shown to possess antioxidant properties in vitro and in vivo. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women. Three groups of sixteen healthy subjects aged 55-70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30 mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4 d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E status were also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55-70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions.

U2 - 10.1079/BJN20061762

DO - 10.1079/BJN20061762

M3 - Article

VL - 95

SP - 1134

EP - 1142

JO - British Journal of Nutrition

T2 - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 6

ER -