Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell Line BRIN-BD11

Pharmacology, Toxicology and Pharmaceutical Science

• Insulin 100%
• Cyclic Nucleotide Phosphodiesterase 100%
• Zaprinast 33%
• Calmodulin 33%
• Rolipram 33%
• Cyclic GMP Phosphodiesterase 33%
• 6 (5,6 Dimethoxybenzo[b]thien 2 Yl) 4,5 Dihydro 5 Methyl 3(2h) Pyridazinone 33%
• Siguazodan 33%
• Calcium 16%
• IC50 16%
• RNA 16%
• Isoenzyme 16%
• Isobutylmethylxanthine 16%
• N (1 Carboxy 3 Phenylpropyl)lysylproline 4 Hydroxybenzamidine 16%
• Cyclic Nucleotide 16%
• Phosphodiesterase V Inhibitor 16%
• Cyclic AMP Phosphodiesterase 16%
• Phosphodiesterase Inhibitor 16%